SYMPOSIUM: Evolution of the Steroid/Thyroid/Retinoic Acid Receptor Family; January 5, 1998, Boston, MA

研讨会：类固醇/甲状腺/视黄酸受体家族的进化；

• 批准号: 9724695
• 负责人: Penny Hopkins
• 金额: $ 0.5万
• 依托单位: University of Oklahoma Norman Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 1998-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9724695&HistoricalAwards=false
• 关键词: SYMPOSIUM; Evolution; Steroid; Thyroid; Retinoic

The rapidly unfolding story of the nuclear receptor superfamily has radically changed the understanding of hormone action. One of the subgroups of that superfamily appears to have evolved at least 500 million years ago prior to the divergence of arthropod and chordate lineages. This subgroup of receptors plays an important role in the control of the complicated events of development and growth. Because of their early divergence, the mechanisms that involve these receptors appear to be very similar in the invertebrates as well as the vertebrates. There have been several international symposia (including both EMBO and Keystone symposia) that address the "form and function" or "the superfamily of nuclear receptors" in general, but until now there has been no systematic attempt to compare the similarities or differences of the form/function of nuclear receptors across phylogenetic lines. The symposium proposed here will bring together researchers working on these receptors and their ligands in a variety of vertebrates and invertebrates. Through this proposed symposium, the PI hopes to foster a broader discussion of the comparative structures of venous receptors, of the degree of post-transcriptional processing of gene products, and of the wide array of developmental and growth-related events that are controlled by this family of transcription factors.

核受体超家族的迅速发展从根本上改变了对激素作用的理解。 该超家族的一个亚群似乎在节肢动物和脊索动物谱系分化之前至少5亿年前就已经进化了。 这种受体亚群在控制发育和生长的复杂事件中起着重要作用。 由于它们的早期分歧，涉及这些受体的机制似乎在无脊椎动物和脊椎动物中非常相似。 已经有几个国际研讨会（包括EMBO和Keystone研讨会），解决了“形式和功能”或“核受体超家族”一般，但到目前为止，还没有系统的尝试，比较的相似性或差异的形式/功能的核受体跨越系统发育线。 这里提议的研讨会将汇集研究这些受体及其配体的研究人员在各种脊椎动物和无脊椎动物。 通过这次拟议的研讨会，PI希望促进静脉受体的比较结构，基因产物的转录后加工的程度，以及由这个转录因子家族控制的广泛的发育和生长相关事件的更广泛的讨论。