The Study of Elusive Neutrals and Ion Structures by Neutralization-Reionization Mass Spectrometry Methods

有机和大分子化学项目支持Chrys wesdemotis教授对中性气相中间体的合成及其中和-再电离质谱表征的研究。中性中间体，如碳炔、硅酮、氨基酸自由基和超金属化物质，将在低动能吸热中和的条件下由相应的大量选择的阳离子或阴离子制备。这些中性中间体的电离能、质子亲和和生成热将从测量的中和吸热性中提取出来。利用被质子连接中和的氨基酸和多肽的不同稳定性和反应性来区分多功能生物分子中的质子结合位点及其相对质子亲和力。进行实验的研究生和本科生将接触到中和-再电离质谱仪的构造，它在不同化学体系中的应用，以及结果数据的分析。有了这个新奖项，有机和大分子化学项目支持阿克伦大学的Chrys wesdemotis教授的研究和教育活动。wesdemotis教授将重点研究中性中间体的合成和表征，这些中间体目前被认为是许多化学转化中的短寿命中间体。许多中间产物将在气相中制备，并在低能中和条件下进行检测，以获得长期寻求的热力学参数。wesdemotis教授的教育活动将包括对本科生和研究生进行中和-再电离质谱理论和应用方面的培训。

The Organic and Macromolecular Chemistry Program supports the studies of Professor Chrys Wesdemiotis on the synthesis of neutral, gas-phase intermediates and their characterization by neutralization-reionization mass spectroscopy. Neutral intermediates, such as carbyne, silanone, amino acid radicals and hypermetalated species, will be prepared from the corresponding mass-selected cations or anions under conditions of endothermic neutralization at low kinetic energy. Ionization energies, proton affinities and heats of formation of these neutral intermediates will be extracted from the measured neutralization endothermicity. The different stabilities and reactivities of amino acids and peptides neutralized by proton attachment will be exploited to distinguish proton binding sites and their relative proton affinities in multi-functional biomolecules. Graduate and undergraduate students carrying out the experiments will be exposed to the construction of the neutralization-reionization mass spectrometer, its application to different chemical systems, and the analysis of the resulting data. With this New award, the Organic and Macromolecular Chemistry Program supports the research and educational activities of Professor Chrys Wesdemiotis of the University of Akron. Professor Wesdemiotis will focus his research on the synthesis and characterization of neutral intermediates that are currently thought to be short-lived intermediates in a number of chemical transformations. A number of intermediates will be prepared in the gas phase and examined under low-energy neutralization conditions in order to obtain long-sought thermodynamic parameters. The educational activities of Professor Wesdemiotis will include the training of undergraduate and graduate students in the theory and applications of neutralization-reionization mass spectroscopy.