The Study of Elusive Neutrals and Ion Structures by Neutralization-Reionization Mass Spectrometry Methods

有机和高分子化学计划支持以下研究： Chrys Weskiovotis教授介绍中性气相合成 中间体及其中和-再电离表征 质谱法 中性中间体，如碳炔，硅烷酮， 氨基酸自由基和超金属化物质，将从 相应的质量选择的阳离子或阴离子的条件下， 在低动能下吸热中和。 电离能， 这些中性中间体的质子亲合势和生成热 将从测量的中和吸热性中提取。 的 氨基酸和肽的不同稳定性和反应性 通过质子附着中和将被用来区分质子 结合位点及其相对质子亲和力 生物分子 研究生和本科生开展 实验将暴露在建设的 中和-再电离质谱仪及其应用 不同的化学系统，以及对所得数据的分析。 有了这个新的奖项，有机和高分子化学计划 支持Chrys教授的研究和教育活动 来自阿克伦大学的韦斯科奥蒂斯说。 维斯基奥蒂斯教授会 他的研究重点是中性的合成和表征， 目前被认为是短暂的中间体 一系列的化学变化。 一些中间体将 在气相中制备并在低能中和下进行检测 条件，以获得长期寻求的热力学参数。 的 教授的教育活动将包括培训 本科生和研究生的理论和应用， 中和-再电离质谱法。

The Organic and Macromolecular Chemistry Program supports the studies of Professor Chrys Wesdemiotis on the synthesis of neutral, gas-phase intermediates and their characterization by neutralization-reionization mass spectroscopy. Neutral intermediates, such as carbyne, silanone, amino acid radicals and hypermetalated species, will be prepared from the corresponding mass-selected cations or anions under conditions of endothermic neutralization at low kinetic energy. Ionization energies, proton affinities and heats of formation of these neutral intermediates will be extracted from the measured neutralization endothermicity. The different stabilities and reactivities of amino acids and peptides neutralized by proton attachment will be exploited to distinguish proton binding sites and their relative proton affinities in multi-functional biomolecules. Graduate and undergraduate students carrying out the experiments will be exposed to the construction of the neutralization-reionization mass spectrometer, its application to different chemical systems, and the analysis of the resulting data. With this New award, the Organic and Macromolecular Chemistry Program supports the research and educational activities of Professor Chrys Wesdemiotis of the University of Akron. Professor Wesdemiotis will focus his research on the synthesis and characterization of neutral intermediates that are currently thought to be short-lived intermediates in a number of chemical transformations. A number of intermediates will be prepared in the gas phase and examined under low-energy neutralization conditions in order to obtain long-sought thermodynamic parameters. The educational activities of Professor Wesdemiotis will include the training of undergraduate and graduate students in the theory and applications of neutralization-reionization mass spectroscopy.