MRI: Acquisition of Matrix-Assisted Laser Desorption Ionization and Electrospray Ionization Mass Spectrometers for the Analysis of New Synthetic Polymers and Materials

MRI：购买基质辅助激光解吸电离和电喷雾电离质谱仪，用于分析新型合成聚合物和材料

• 批准号: 0821313
• 负责人: Chrys Wesdemiotis
• 金额: $ 78.86万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0821313&HistoricalAwards=false
• 关键词: MRI; Acquisition; Matrix; Assisted; Laser

Technical AbstractMatrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI) mass spectrometers will be acquired for the analysis of synthetic, macromolecular materials. The instruments will support a variety of interdisciplinary research programs in polymer science and engineering at the University of Akron, which focus on the creation of new polymers and materials and the examination of these substances for specific applications. The studies performed within this research regularly raise questions about the mass, composition, functional groups, purity, connectivity, and architecture of functionalized oligomers and macromonomers, hyperbranched and dendritic systems, organic and inorganic polymers, copolymers, polymer interfaces, and polymer-biomolecule conjugates. These questions can be answered with exceptional sensitivity and specificity by combined MALDI time-of-flight and ESI ion trap / time-of-flight mass spectrometry analyses. The high resolution, high mass accuracy, and tandem mass spectrometry capabilities of the instruments to be obtained will significantly facilitate the desired structural characterizations, fostering the development of new methods of polymerization and the discovery of new materials with properties fine-tuned for particular technological uses, inter alia, in photovoltaic devices, sensors, or drug delivery systems. The instruments will be accessible to industrial researchers and college faculty from Northeast Ohio, who need ESI or MALDI mass spectrometry to solve their analytical problems. They will also be available for a variety of educational activities, including instrumental analysis courses and research courses for graduate, undergraduate, REU, and McNair students.Non-Technical AbstractThe University of Akron (UA) will purchase instruments to study structure and enhance research and education in many interconnected research projects in polymer science and engineering. Currently, researchers at UA focus on the preparation of new materials; on the mechanical, physical, and chemical properties of these materials; and on the optimization of their properties for specific applications in nanotechnology and biomedical fields. For example, materials for light harvesting devices, biosensors, stents, implants, and drug delivery systems are being studied. The research naturally leads to questions about the chemical make-up, size, and purity of the materials. The mass spectrometry equipment requested will enable rapid and accurate measurement of these properties and lead to the making of new materials. The problem solving capability of the instruments will make the discovery of new materials easier and allow the properties of the materials to be fine-tuned for the desired use. The instruments will be used by academic and industrial researchers within the Ohio Mass Spectrometry Consortium (universities, other research institutions, and affiliated industrial corporations) as well as by college faculty from universities in Northeast Ohio. The instruments will also be available for a variety of educational activities, including undergraduate courses in instrumental analysis and research courses for graduate and undergraduate students.

技术摘要基质辅助激光解吸电离（MALDI）和电喷雾电离（ESI）质谱仪将用于合成高分子材料的分析。 这些仪器将支持阿克伦大学聚合物科学和工程领域的各种跨学科研究项目，这些项目的重点是创造新的聚合物和材料，并对这些物质的特定应用进行检查。 在本研究中进行的研究经常提出有关质量，组成，官能团，纯度，连接性和结构的官能化低聚物和大分子单体，超支化和树枝状系统，有机和无机聚合物，共聚物，聚合物界面，和聚合物-生物分子共轭物的问题。 这些问题可以通过结合MALDI飞行时间和ESI离子阱/飞行时间质谱分析以异常的灵敏度和特异性来回答。 所获得的仪器的高分辨率、高质量准确度和串联质谱能力将显著促进所需的结构表征，促进新聚合方法的开发和具有针对特定技术用途（阿利亚是在光伏器件、传感器或药物递送系统中）微调的特性的新材料的发现。 这些仪器将提供给俄亥俄州东北部的工业研究人员和大学教师，他们需要ESI或MALDI质谱仪来解决他们的分析问题。 他们也将可用于各种教育活动，包括研究生，本科生，REU和McNair学生的仪器分析课程和研究课程。非技术摘要阿克伦大学（UA）将购买仪器来研究结构，并加强在聚合物科学和工程的许多相互关联的研究项目的研究和教育。 目前，UA的研究人员专注于新材料的制备;这些材料的机械，物理和化学特性;以及在纳米技术和生物医学领域的特定应用中优化其特性。 例如，正在研究用于光捕获装置、生物传感器、支架、植入物和药物输送系统的材料。 这项研究自然会引发有关材料的化学组成、大小和纯度的问题。 所要求的质谱设备将能够快速准确地测量这些特性，并导致新材料的制造。 这些仪器解决问题的能力将使新材料的发现更容易，并允许对材料的性能进行微调以满足所需的用途。 这些仪器将由俄亥俄州质谱联盟（大学、其他研究机构和附属工业公司）的学术和工业研究人员以及俄亥俄州东北部大学的学院教师使用。 这些仪器还将用于各种教育活动，包括仪器分析本科课程和研究生和本科生的研究课程。