Gas Phase Chemistry of Radicals and Charged Radicals

自由基和带电自由基的气相化学

• 批准号: 0111128
• 负责人: Chrys Wesdemiotis
• 金额: $ 22.2万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-10-01 至 2005-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0111128&HistoricalAwards=false
• 关键词: Gas; Phase; Chemistry; Radicals; Charged

With the support of the Organic and Macromolecular Chemistry Program, Professor Chrys Wesdemiotis, of the Department of Chemistry at the University of Akron, is studying the gas phase chemistry of radicals and charged radicals. Neutralization-reionization mass spectrometry is employed to obtain experimental data regarding the stabilities and unimolecular reactions of radicals related to amino acids, peptides, and nucleobases. Focus is placed on the alteration of stability and reaction chemistry caused by the replacement of acidic hydrogen atoms with metal ions. The synthesis and characterization of distonic radical cations containing a metal ion and an organic radical site are also under investigation. These metal ion-containing (and hence, charged) radicals will be used as templates for the investigation of free radical chemistry by tandem mass spectrometry. Solvated charged radicals will be utilized to derive thermochemical data about amino acid and peptide-based radicals.Molecules and ions containing unpaired electrons ("radicals") play central roles in many chemical and biochemical processes. Development of a detailed understanding of the structure and reactivity of these elusive species remains a key focus of modern chemical research. With the support of the Organic and Macromolecular Chemistry Program, Professor Chrys Wesdemiotis, of the Department of Chemistry at the University of Akron, is generating and studying radicals related to amino acids, proteins, and nucleic acid bases. Through these studies, Professor Wesdemiotis is gaining a fundamental understanding of the chemistry of these important species, implicated as key intermediates in the oxidative damage of proteins and nucleic acids.

在有机和高分子化学计划的支持下，阿克伦大学化学系的Chrys Wesquitotis教授正在研究自由基和带电自由基的气相化学。采用中和-再电离质谱法获得有关氨基酸、肽和核碱基相关自由基的稳定性和单分子反应的实验数据。重点放在改变的稳定性和反应化学所造成的酸性氢原子与金属离子的替代。含有金属离子和有机自由基位点的二阶自由基阳离子的合成和表征也在研究中。这些含金属离子（因此，带电）的自由基将被用作模板，通过串联质谱法研究自由基化学。溶剂化的带电自由基将被用于推导氨基酸和肽基的热化学数据。含有不成对电子的分子和离子（“自由基”）在许多化学和生物化学过程中起着核心作用。对这些难以捉摸的物种的结构和反应性的详细了解仍然是现代化学研究的重点。在有机和大分子化学计划的支持下，阿克伦大学化学系的Chrys Wesquitotis教授正在生成和研究与氨基酸，蛋白质和核酸碱基相关的自由基。通过这些研究，Wesperiotis教授对这些重要物种的化学性质有了基本的了解，这些物种是蛋白质和核酸氧化损伤的关键中间体。