Spatially-Encoded Combinatorial Chemistry: A New Approach with Significant Information-Processing Advantages

空间编码组合化学：具有显着信息处理优势的新方法

• 批准号: 9726030
• 负责人: Alan Schwabacher
• 金额: $ 5万
• 依托单位: University of Wisconsin-Milwaukee
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9726030&HistoricalAwards=false
• 关键词: Spatially; Encoded; Combinatorial; Chemistry; New

This project addresses the development and exploitation of a simple technique for preparation of combinatorial libraries of compounds whose synthetic histories are encoded by position along a one-dimensional solid support. This approach combines the attractive statistical control, simplicity, and flexibility of the split-mix synthetic procedure with the full library analysis of a spatial encoding approach. Equipment requirements are simpler than those for other spatial-encoding techniques, and Fourier transformation of the signal output will lead directly to structure-activity relationships. With the support of a Small Grant for Exploratory Research from the Organic Synthesis Program, Professor Alan W. Schwabacher, of the Department of Chemistry at the University of Wisconsin, Milwaukee, is developing an approach for the generation and analysis of combinatorial libraries. By adapting known methods for the preparation of such `libraries` (groups of related compounds) to incorporate the libraries along a one-dimensional solid support, these studies may lead to the development of techniques requiring only simple equipment and permitting rapid analysis of structure-activity relationships.

该项目致力于开发和利用一种简单的技术来制备化合物的组合库，其合成历史由沿着一维固体支持物的位置编码。 这种方法将分割混合合成过程的有吸引力的统计控制、简单性和灵活性与空间编码方法的完整库分析结合起来。 设备要求比其他空间编码技术更简单，信号输出的傅立叶变换将直接导致结构-活性关系。在有机合成计划探索性研究小额资助的支持下，威斯康星大学密尔沃基分校化学系的 Alan W. Schwabacher 教授正在开发一种生成和分析组合文库的方法。 通过采用已知的制备此类“文库”（相关化合物组）的方法，将文库合并到一维固体支持物上，这些研究可能会导致只需要简单设备并允许快速分析结构-活性关系的技术的发展。