Spatially-Encoded Combinatorial Chemistry: A New Approach with Significant Information-Processing Advantages

本项目致力于开发和利用一种简单的技术来制备化合物的组合文库，这些化合物的合成历史是沿着一维固体支撑按位置编码的。这种方法结合了分割-混合合成过程的统计控制、简单性和灵活性，以及空间编码方法的完整库分析。设备要求比其他空间编码技术更简单，信号输出的傅里叶变换将直接导致结构-活动关系。在有机合成项目探索性研究小额资助的支持下，威斯康星大学密尔沃基分校化学系的Alan W. Schwabacher教授正在开发一种生成和分析组合库的方法。通过采用已知的方法来制备这些“文库”（相关化合物的基团），使文库沿着一维固体载体结合，这些研究可能会导致技术的发展，只需要简单的设备，就可以快速分析结构-活性关系。

This project addresses the development and exploitation of a simple technique for preparation of combinatorial libraries of compounds whose synthetic histories are encoded by position along a one-dimensional solid support. This approach combines the attractive statistical control, simplicity, and flexibility of the split-mix synthetic procedure with the full library analysis of a spatial encoding approach. Equipment requirements are simpler than those for other spatial-encoding techniques, and Fourier transformation of the signal output will lead directly to structure-activity relationships. With the support of a Small Grant for Exploratory Research from the Organic Synthesis Program, Professor Alan W. Schwabacher, of the Department of Chemistry at the University of Wisconsin, Milwaukee, is developing an approach for the generation and analysis of combinatorial libraries. By adapting known methods for the preparation of such `libraries` (groups of related compounds) to incorporate the libraries along a one-dimensional solid support, these studies may lead to the development of techniques requiring only simple equipment and permitting rapid analysis of structure-activity relationships.