One-Dimensional Spatially-Encoded Combinatorial Chemistry with Fourier Transform Library Analysis

具有傅里叶变换库分析的一维空间编码组合化学

• 批准号: 9874241
• 负责人: Alan Schwabacher
• 金额: $ 32.25万
• 依托单位: University of Wisconsin-Milwaukee
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2004-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9874241&HistoricalAwards=false
• 关键词: Dimensional; Spatially; Encoded; Combinatorial; Chemistry

This research project explores new methodologies for combinatorial synthesis and screening, based on Fourier transform analysis of one-dimensional libraries compiled on various types of threads. The chemistry involves establishing compatible combinations of solid supports (cotton or other threads) and reagents appropriate for the synthesis of different types of molecules. Application of the method to protein-binding peptides is proposed, as well as study of the binding selectivity of synthetic receptors and further development of data collection and analysis.With this award, the Organic and Macromolecular Chemistry Program supports the research of Professor Alan W. Schwabacher of the University of Wisconsin at Milwaukee. Dr. Schwabacher is exploring ways to make very large numbers of different molecules in minute quantities and in a single batch. This is to be done in such a way that the properties of each type of molecule can be evaluated while keeping track of the exact structure of each molecule. This makes possible the evaluation of a large number of potentially useful molecules without the need to synthesize each one separately, until after its properties are known.

该研究项目探索了组合合成和筛选的新方法，基于对各种类型线程上编译的一维库的傅立叶变换分析。 化学过程包括建立固体支持物（棉花或其他线）和适合于合成不同类型分子的试剂的相容组合。 该方法的应用，蛋白质结合肽的建议，以及研究合成受体的结合选择性和进一步发展的数据收集和分析。位于密尔沃基的威斯康星州大学的施瓦巴赫。 Schwabacher博士正在探索一种方法，以微小的数量和一批生产大量不同的分子。 这是以这样一种方式完成的，即可以在跟踪每个分子的确切结构的同时评估每种分子的性质。 这使得大量潜在有用分子的评估成为可能，而无需单独合成每一个分子，直到其性质已知。