A New Class of "Heteroscorpionate" Ligands for Inorganic Chemistry

一类新的无机化学“异蝎”配体

• 批准号: 9726488
• 负责人: Carl Carrano
• 金额: $ 15.6万
• 依托单位: Texas State University - San Marcos
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9726488&HistoricalAwards=false
• 关键词: New; Class; Heteroscorpionate; Ligands; Inorganic

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research in the laboratory of Professor Carl J. Carrano at Southwest Texas State University under the initiative on Research at Undergraduate Institutions. This research will explore the chemistry of `scorpionate` complexes. Scorpionates are trispyrazoly-borate and -methane ligands, which are facially coordinating and stabilize metals in a variety of oxidation states. A general synthetic route into heteroscorpionate ligands, which would incorporate a biologically relevant donor (thiol, phenol, carboxylate, etc.) as the `stinger` tail along with two pyrazolyl `claws,` will be developed. The facially coordinating nature of these ligands together with the introduction of heteroatoms will provide the basis for studying these compounds as models for metal ion active sites in proteins, such as as nitrile hydratase. This research at a primarily undergraduate institution will undertake the preparation of new complexes with ligands that will allow the compounds to serve as models for metal-centered active sites in proteins.

该奖项在无机、生物无机和有机金属化学项目中，支持西南德克萨斯州立大学Carl J. Carrano教授实验室在本科院校研究倡议下的研究。这项研究将探索“蝎子酸”复合物的化学性质。蝎蝎酸盐是三吡唑硼酸盐和甲烷配体，具有表面配位和稳定金属在各种氧化态。将开发一种合成异蝎酸配体的一般路线，该路线将包含一个生物学上相关的供体（硫醇、苯酚、羧酸盐等）作为“毒刺”尾巴和两个吡唑基“爪子”。这些配体的表面配位特性以及杂原子的引入将为研究这些化合物作为蛋白质（如腈水合酶）中金属离子活性位点的模型提供基础。这项研究主要是在一所本科院校进行的，将进行新的配体复合物的制备，这些配体将允许这些化合物作为蛋白质中金属中心活性位点的模型。