Synthesis and Applications of Enantiomerically Pure Helicates

对映体纯螺旋酸酯的合成及应用

• 批准号: 9729214
• 负责人: Geoffrey Coates
• 金额: $ 4万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9729214&HistoricalAwards=false
• 关键词: Synthesis; Applications; Enantiomerically; Pure; Helicates

This starter grant award of the Chemistry Division to Cornell University supports the research of Professor Geoffrey W. Coates. The themes of the research are synthesis and application of enantiomerically pure helicates. Work is directed to the synthesis of two classes of optically active ligands that are specifically designed to form enantiomerically pure helicates in the presence of metal ions that prefer tetrahedral coordination geometries. Investigations include the mechanism of helix wrapping and unwinding and the application of helicates as catalysts for asymetric synthesis. The project, with components of organic synthesis, inorganic stereochemistry, and catalysis, facilitates the comprehensive training of graduate students. The research leads to the synthesis of a new class of optically active compounds whose helical structures resemble those of proteins and nucleic acids. Applications provide new opportunities in the fields of enantioselective catalysis, biochemistry, and molecular topology.

化学系授予康奈尔大学的这笔初学者奖金支持杰弗里·W·科茨教授的研究。本研究的主题是对映体纯螺旋化合物的合成及其应用。工作是针对合成两类光学活性配体，这两类配体是专门设计在偏爱四面体配位几何构型的金属离子存在的情况下形成对映体纯螺旋。研究内容包括螺旋缠绕和解旋的机理以及螺旋作为催化剂在不对称合成中的应用。该项目包含有机合成、无机立体化学和催化等组成部分，有利于研究生的综合培养。这项研究导致合成了一类新的光学活性化合物，其螺旋结构类似于蛋白质和核酸的螺旋结构。在对映体选择性催化、生物化学和分子拓扑学领域的应用提供了新的机会。