Neuronal mechanisms of pheromone sensing

信息素感知的神经机制

• 批准号: 122941022
• 负责人: Professor Dr. Ulrich Boehm
• 金额: --
• 依托单位: FR Experimentelle und Klinische Pharmakologie und Toxikologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/122941022?language=en
• 关键词: Neuronal; mechanisms; pheromone; sensing

Chemosensory cues are known to influence sexual behavior and reproductive physiology. Yet, how the olfactory system impinges onto different output neurons in the brain that are mediating these effects remains largely unknown. We would like to dissect the underlying neural circuitry and study the fundamental physiological mechanisms that govern reproduction in mice by integrating genetic, molecular, cellular, and system approaches. In this next funding period we propose to focus our analysis on the functional role of the newly-identified GnRHR neuron populations in the amygdala and PAG, respectively. Our previous results demonstrate that GnRHR neurons in these areas respond reproducibly to extracellular application of GnRH. Based on these results, we hypothesize that neuroendocrine state-dependent activation of amygdala GnRHR neurons will contribute to olfactory memory whereas pheromone-triggered activation of PAG GnRHR neurons will modulate female sexual (lordosis) behavior. We will directly test these hypotheses in living animals using fiber optics and light pulses while monitoring the animal's behavior.

已知化学感应信号会影响性行为和生殖生理学。然而，嗅觉系统如何影响大脑中介导这些效应的不同输出神经元仍然很大程度上未知。我们希望通过整合遗传、分子、细胞和系统方法来剖析潜在的神经回路，并研究控制小鼠繁殖的基本生理机制。在下一个资助期内，我们建议将分析重点分别放在杏仁核和 PAG 中新识别的 GnRHR 神经元群的功能作用上。我们之前的结果表明，这些区域的 GnRHR 神经元对 GnRH 的细胞外应用具有可重复的反应。基于这些结果，我们假设杏仁核 GnRHR 神经元的神经内分泌状态依赖性激活将有助于嗅觉记忆，而信息素触发的 PAG GnRHR 神经元激活将调节女性性（脊柱前凸）行为。我们将使用光纤和光脉冲在活体动物中直接测试这些假设，同时监测动物的行为。

项目成果

TAS2R bitter taste receptors regulate thyroid function

• DOI: 10.1096/fj.14-262246
• 发表时间: 2015-01-01
• 期刊: FASEB JOURNAL
• 影响因子: 4.8
• 作者: Clark, Adam A.;Dotson, Cedrick D.;Munger, Steven D.
• 通讯作者: Munger, Steven D.

Transsynaptic Tracing from Taste Receptor Cells Reveals Local Taste Receptor Gene Expression in Gustatory Ganglia and Brain

• DOI: 10.1523/jneurosci.0381-15.2015
• 发表时间: 2015-07
• 期刊: The Journal of Neuroscience
• 作者: A. Voigt;Juliane Bojahr;M. Narukawa;Sandra Hübner;U. Boehm;W. Meyerhof

TRP channels in reproductive (neuro)endocrinology.

生殖（神经）内分泌学中的 TRP 通道

• DOI: 10.1007/978-3-319-05161-1_16
• 发表时间: 2014
• 期刊: Handbook of experimental pharmacology
• 作者: Leinders-Zufall T;Boehm U
• 通讯作者: Boehm U

A Family of Nonclassical Class I MHC Genes Contributes to Ultrasensitive Chemodetection by Mouse Vomeronasal Sensory Neurons

• DOI: 10.1523/jneurosci.0186-14.2014
• 发表时间: 2014-04-09
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Leinders-Zufall, Trese;Ishii, Tomohiro;Mombaerts, Peter
• 通讯作者: Mombaerts, Peter

Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in mice.

• DOI: 10.1093/chemse/bjs082
• 发表时间: 2012-11
• 期刊: Chemical senses
• 影响因子: 3.5
• 作者: A. Voigt;Sandra Hübner;Kristina Lossow;I. Hermans-Borgmeyer;U. Boehm;W. Meyerhof