Functional mechanisms of environmental control over social behavior

环境控制社会行为的功能机制

• 批准号: 10723779
• 负责人: Philipp Brand
• 金额: $ 12.5万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10723779
• 关键词: Address; Advisory Committees; Anatomy; Architecture; Award; Bacteria; Behavior; Behavior Control; Behavioral; Biology; Birds; Brain; Brain imaging; Chemicals; Code; Complement; Copulation; Courtship; Cues; Decision Making; Development Plans; Drosophila genus; Drosophila melanogaster; Ecology; Elements; Environment; Ethology; Exposure to; Failure; Female; Food; Functional Imaging; Genetic Complementation Test; Goals; Human; Image; Individual; Interneurons; Light; Link; Mammals; Mental Depression; Mentors; Mentorship; Modeling; Mus; Nervous System; Neuroanatomy; Neurons; Neurosciences; Odors; Olfactory Pathways; Partner in relationship; Perception; Phase; Pheromone; Play; Population; Population Control; Positioning Attribute; Probability; Process; Psychology; Regulation; Reproductive Behavior; Research; Resources; Role; Ruta; Schizophrenia; Sensory; Sex Attractants; Shapes; Signal Transduction; Social Behavior; Social Controls; Social Environment; Social Interaction; Stimulus; System; Techniques; Testing; Traction; Training; Translating; Universities; Variant; Visual; Visual Pathways; Volatilization; Wolbachia; Work; autism spectrum disorder; career development; comparative; design; fly; in vivo; insight; male; mating behavior; microbial; microorganism; multimodality; neural; neural circuit; neurogenetics; neuromechanism; neuropsychiatric disorder; neuropsychiatry; novel; operation; optogenetics; preference; sensory input; sensory integration; skills; social; social group; virtual reality; virtual reality system

Project Summary Environmental cues and signals are fundamental in the regulation of behavioral decision making. For decades this aspect of social behavior has been a major focus of environmental psychology and neuropsychiatry research. Yet the complexity of the mammalian nervous system and the lack of experimental traction in humans has limited a mechanistic understanding of how environmental influences shape sensory processing and social behavior. The goal of this proposal is to take advantage of the comparatively simple nervous system of Drosophila to identify the functional neural basis of environmental control over social behaviors, which has the potential to inform our understanding of devastating neuropsychiatric conditions characterized by the failure to appropriately process social and other environmental cues. In my experimental approach I leverage the power of striking natural variation in the environmental control over mating behaviors across species in a comparative framework and combine it with the unparalleled neurogenetic toolkit of Drosophila to isolate causal neural circuit mechanisms through which environmental cues control behavior. In the mentored phase of this award, I will elucidate the functional integration of food odors with male courtship circuits (Aim 1) and characterize how visual cues emitted by the social group regulate female copulation decisions (Aim 2) using a combination of in vivo functional brain imaging in a multimodal virtual reality system, optogenetics, and neuroanatomy approaches across two species with divergent behaviors. The comparison of alternative circuit architectures underlying behavioral differences will allow me to isolate the circuit motifs and dynamics that control the functional integration of these environmental cues with central mating circuits. For the independent phase of the award, I will transfer the skills and techniques acquired during the training phase to develop a new model for comparative neuroscience. This will allow me to elucidate the neuronal functional principles underlying bacterial manipulations of the nervous system that alter the perception of environmental signals and manipulate mating behavior of infected individuals in the bacteria’s favor (Aim 3). The proposed professional development plan under the continued mentorship of Dr. Vanessa Ruta complements my training in evolutionary biology, chemical ecology and systems neuroscience with the background and techniques necessary to complete the proposed research and shed new light on the functional mechanisms of environmental control over social behavior. To achieve these goals, I will take advantage of the extensive resources of the Rockefeller University and my advisory committee, that will provide expert guidance in key aspects of the project and career development. Together this will set me up optimally to successfully transition to an independent position and start my own lab exploring the mechanisms underlying the sensory control of behavior at the intersection of neuroscience and evolutionary biology.

项目摘要 环境线索和信号是调节行为决策的基础。几十年来 社会行为的这一方面一直是环境心理学和神经精神病学的主要焦点。 研究。然而，哺乳动物神经系统的复杂性和人类实验牵引力的缺乏 限制了对环境如何影响感觉加工和社交的机械性理解 行为。这项提议的目标是利用人类相对简单的神经系统 果蝇识别环境控制社会行为的功能神经基础，这具有 有可能让我们了解毁灭性的神经精神疾病，其特征是 适当地处理社会和其他环境线索。在我的实验方法中，我利用 在不同物种的交配行为的环境控制中的显著自然变异 框架，并将其与果蝇无与伦比的神经遗传学工具包相结合，分离因果神经回路 环境线索控制行为的机制。 在这个奖项的指导阶段，我将阐明食物气味与男性求爱的功能整合 环路(目标1)，并描述社会群体发出的视觉线索如何调节雌性交配 决策(目标2)在多模式虚拟现实系统中使用体内功能脑成像的组合， 光遗传学和神经解剖学方法跨越两个行为不同的物种。两种方法的比较 行为差异背后的替代电路体系结构将使我能够分离电路主题和 控制这些环境信号与中央交配回路的功能整合的动力学。对于 在奖项的独立阶段，我将把在培训阶段获得的技能和技能转移到 开发一种新的比较神经科学模型。这将使我能够阐明神经元的功能 改变环境感知的神经系统细菌操作的基本原理 发出有利于细菌的信号并操纵受感染个体的交配行为(目标3)。 在Vanessa Ruta博士的持续指导下拟议的专业发展计划是对 我在进化生物学、化学生态学和系统神经科学方面的培训，背景和 完成拟议的研究所需的技术，并对 环境对社会行为的控制。为了实现这些目标，我将利用广泛的 洛克菲勒大学和我的顾问委员会的资源，将在关键领域提供专家指导 项目和职业发展的各个方面。总而言之，这将为我成功过渡做好最佳准备 到一个独立的位置，开始我自己的实验室，探索潜在的感官控制的机制 神经科学和进化生物学交汇处的行为。