Incorporation of Fourier Transform Nuclear Magnetic Resonance Spectroscopy into the Undergraduate Chemistry Curriculum

将傅里叶变换核磁共振波谱纳入本科化学课程

• 批准号: 9751634
• 负责人: Edgar Drake
• 金额: $ 5.93万
• 依托单位: Angelo State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9751634&HistoricalAwards=false
• 关键词: Incorporation; Fourier; Transform; Nuclear; Magnetic

The Chemistry Department has been in the process of redesigning its undergraduate laboratories in order to provide students with exposure to modern chemical instrumentation and current laboratmry techniques. The department is acquiring a 200 MHz Fourier-transform nuclear-magnetic resonance (FT-NMR) that complements the department's existing instrumentation. The 200 MHz FT-NMR is replacing an inoperable 90 MHz CW-NMR, and enabling the department to expose students to nuclear-magnetic resonance (NMR) techniques frequently during their chemistry training. The sequence of laboratory exercises is allowing NMR instruction to begin early and proceed with increasing depth as students progress in the chemistry program. Microscale experiments have been incorporated into the organic curriculum, as well as the synthesis and subsequent analysis of a locally occurring dye. NMR analysis of products can contribute greatly to the instructional value of this laboratory. In the physical chemistry laboratory, the instrument is being used to determine rate constants for a reaction at equilibrium and illustrate Heisenberg uncertainty relationships evident as line broadening. Two-dimensional NMR is also being introduced, during the instrumental analysis laboratory, in the context of sequencing short peptides. The department is also integrating this spectrometer into the biochemistry and molecular biology laboratory by having students determine the sequence of a 10 base-pair DNA duplex. Exposing chemistry students to NMR theory and applications through the department's laboratory courses, including individual research, is greatly enhancing their overall research experience.

化学系一直在重新设计其本科实验室的过程中，以提供接触现代化学仪器和当前的实验室技术的学生。 该部门正在购买一台200 MHz傅里叶变换核磁共振（FT-NMR），以补充该部门现有的仪器。 200 MHz FT-NMR正在取代无法操作的90 MHz CW-NMR，并使该部门能够在化学培训期间经常让学生接触核磁共振（NMR）技术。 实验室练习的顺序是允许核磁共振教学开始早，并进行越来越深入的学生在化学课程的进展。 微型实验已被纳入有机课程，以及合成和随后的分析当地发生的染料。 产物的核磁共振分析对本实验室的教学价值有很大的贡献。 在物理化学实验室中，该仪器被用于确定平衡反应的速率常数，并说明海森堡不确定性关系，如谱线展宽。 在仪器分析实验室中，在短肽测序的背景下，也引入了二维NMR。 该部门还通过让学生确定10个碱基对DNA双链体的序列，将该光谱仪整合到生物化学和分子生物学实验室中。 通过该部门的实验室课程，包括个人研究，使化学专业的学生接触NMR理论和应用，极大地提高了他们的整体研究经验。