Incorporation of Fourier Transform Nuclear Magnetic Resonance Spectroscopy into the Undergraduate Chemistry Curriculum

化学系一直在重新设计其本科实验室，以便为学生提供接触现代化学仪器和当前实验室技术的机会。该部门正在购买一台200 MHz傅立叶变换核磁共振(FT-核磁共振)，以补充该部门现有的仪器。200 MHz FT-核磁共振正在取代无法操作的90 MHz CW-核磁共振，并使该系能够在化学培训期间频繁地让学生接触核磁共振(核磁共振)技术。实验室练习的顺序使核磁共振教学可以尽早开始，并随着学生在化学项目中的进步而不断深入。微型实验已被纳入有机课程，以及合成和随后分析当地出现的一种染料。产品的核磁共振分析对本实验室有很大的指导意义。在物理化学实验室中，该仪器被用来确定平衡反应的速率常数，并说明海森伯不确定度关系，明显表现为线条加宽。在仪器分析实验室中，在对短肽进行测序的背景下，也引入了二维核磁共振。该系还将这种光谱仪集成到生物化学和分子生物学实验室，让学生确定10个碱基对的DNA双链的序列。通过化学系的实验室课程，包括个人研究，让化学学生接触核磁共振理论和应用，大大提高了他们的整体研究体验。

The Chemistry Department has been in the process of redesigning its undergraduate laboratories in order to provide students with exposure to modern chemical instrumentation and current laboratmry techniques. The department is acquiring a 200 MHz Fourier-transform nuclear-magnetic resonance (FT-NMR) that complements the department's existing instrumentation. The 200 MHz FT-NMR is replacing an inoperable 90 MHz CW-NMR, and enabling the department to expose students to nuclear-magnetic resonance (NMR) techniques frequently during their chemistry training. The sequence of laboratory exercises is allowing NMR instruction to begin early and proceed with increasing depth as students progress in the chemistry program. Microscale experiments have been incorporated into the organic curriculum, as well as the synthesis and subsequent analysis of a locally occurring dye. NMR analysis of products can contribute greatly to the instructional value of this laboratory. In the physical chemistry laboratory, the instrument is being used to determine rate constants for a reaction at equilibrium and illustrate Heisenberg uncertainty relationships evident as line broadening. Two-dimensional NMR is also being introduced, during the instrumental analysis laboratory, in the context of sequencing short peptides. The department is also integrating this spectrometer into the biochemistry and molecular biology laboratory by having students determine the sequence of a 10 base-pair DNA duplex. Exposing chemistry students to NMR theory and applications through the department's laboratory courses, including individual research, is greatly enhancing their overall research experience.