POWRE: Application of Immunological Methods to the Study of Ancient Tissues

POWRE：免疫学方法在古代组织研究中的应用

• 批准号: 9753187
• 负责人: Mary Schweitzer
• 金额: $ 7.5万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9753187&HistoricalAwards=false
• 关键词: POWRE; Application; Immunological; Methods; Study

9753187 Schweitzer The goal of this study is to characterize the immunogenicity and antigenicity of organic compounds associated with unpermineralized bony tissues from Cretaceous specimens. The specific aims are to chemically extract minimally altered tissues and to characterize components within these extracts through a variety of analytical and reflect original molecular structure can be extracted from fossilized remains and that the immunological reactivity of these compounds can be used to study evolutionary relationships of extinct organisms. Technological advances in the last two decades have greatly increased the sensitivity of molecular analyses. Application of these technologies to ancient tissues has made it possible to extract molecular information from extinct organisms, shedding light on phylogenetic relationships and evolutionary processes. Molecular paleontology has focused primarily on Holocene remains with remarkable success; application of these same technologies to Cretaceous specimens is uncommon. However, recent studies have demonstrated the feasibility of applying immunological methods to well preserved and minimally altered Cretaceous specimens.

小行星9753187 本研究的目的是表征与白垩纪标本未矿化骨组织相关的有机化合物的免疫原性和抗原性。 具体目标是化学提取最小程度改变的组织，并通过各种分析表征这些提取物中的组分，并反映原始分子结构可以从化石遗骸中提取，这些化合物的免疫反应性可用于研究灭绝生物的进化关系。 近二十年来的技术进步大大提高了分子分析的灵敏度。 将这些技术应用于古老的组织，使人们有可能从灭绝的生物体中提取分子信息，揭示系统发育关系和进化过程。 分子古生物学主要集中在全新世遗骸上，取得了显着的成功;将这些相同的技术应用于白垩纪标本并不常见。 然而，最近的研究已经证明了将免疫学方法应用于保存完好且变化最小的白垩纪标本的可行性。