Development of Chemoenzymatic Routes to Bioactive Molecules

生物活性分子化学酶途径的开发

• 批准号: 9801679
• 负责人: Carl Johnson
• 金额: $ 42.6万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9801679&HistoricalAwards=false
• 关键词: Development; Chemoenzymatic; Routes; Bioactive; Molecules

The focus of this research is the use of catalytic enzymatic reactions with readily accessible starting materials to afford enantiopure building blocks that can be converted, by means of catalytic transition metal reactions, into complex molecules having interesting biological properties. The methodology will be used to synthesize sugar analogs, amino acids, glycoproteins and zaragozic acids. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Carl R. Johnson of the Department of Chemistry at Wayne State University. Professor Johnson will focus his work on developing new applications of enzymes as catalysts in key steps of the synthesis of complex organic molecules. The project will provide training of the participants including undergraduates, graduate students and postdoctoral associates in a wide range of very contemporary procedures and methods and, in doing so, will provide highly qualified persons for economically important chemical industries, especially the pharmaceutical and agricultural chemistry industries.

这项研究的重点是利用催化酶反应和容易获得的起始材料来提供对映纯的构建块，这些构建块可以通过催化过渡金属反应转化为具有有趣生物特性的复杂分子。该方法将用于合成糖类似物、氨基酸、糖蛋白和杂二酸。有了这个更新奖，有机和大分子化学项目支持韦恩州立大学化学系的Carl R. Johnson博士的研究。约翰逊教授将专注于开发酶作为催化剂在复杂有机分子合成关键步骤中的新应用。该项目将为包括本科生、研究生和博士后在内的参与者提供各种非常现代的程序和方法的培训，从而为经济上重要的化学工业，特别是制药和农业化学工业提供高素质的人才。