Development of Chemoenzymatic Approaches to Bioactive Molecules

合成有机项目正在支持卡尔·R·约翰逊博士在韦恩州立大学化学系的研究。旨在促进酶作为催化剂在合成复杂有机分子的关键步骤中的应用的研究将是该项目的重点。所提出的酶的介观底物很容易从环庚三烯等起始材料中产生，是稠密官能化的环状化合物。酶反应将有助于揭示多个手性中心，并产生化合物，这些化合物应该是进一步合成操作的有用构件。目标分子将包括泛司他汀、四氢脂抑素和与两性霉素B相关的化合物。为了回收许多感兴趣的酶，研究的一个组成部分将涉及开发基于含有氮内酯基团的新聚合物的酶固定化新通用技术。

The Synthetic Organic Program is supporting the research of Dr. Carl R. Johnson in the Department of Chemistry at Wayne State University. Studies designed to advance the applications of enzymes as catalysts in key steps of the synthesis of complex organic molecules will be the focus of the project. The proposed meso substrates for the enzymes, easily produced from starting materials such as cycloheptatriene, are densely funtionalized cyclic compounds. The enzymatic reactions will serve to unveil multiple chiral centers and result in compounds that should be useful building blocks for futher synthetic manipulation. Target molecules will include pancrastistatin, tetrahydrolipstatin and compounds related to amphotericin B. In order to recycle many of the enzymes of interest, an integral part of the study will involve the development of new general technology for the immobilization of enzymes based on a new polymer containing azlactone groups.