Development of Chemoenzymatic Approaches to Bioactive Molecules

合成有机项目支持韦恩州立大学化学系卡尔·r·约翰逊博士的研究。旨在促进酶作为催化剂在复杂有机分子合成关键步骤中的应用的研究将是该项目的重点。提议的酶的中介底物很容易从诸如环庚三烯的起始材料中产生，是密集功能化的环状化合物。酶促反应将有助于揭示多个手性中心，并产生化合物，这些化合物应该是进一步合成操作的有用基石。目标分子将包括pancrastistatin， tetrahydrolipstatin和与两性霉素b相关的化合物。为了回收许多感兴趣的酶，研究的一个组成部分将涉及基于含有氮唑内酯基团的新聚合物的酶固定化的新通用技术的开发。

The Synthetic Organic Program is supporting the research of Dr. Carl R. Johnson in the Department of Chemistry at Wayne State University. Studies designed to advance the applications of enzymes as catalysts in key steps of the synthesis of complex organic molecules will be the focus of the project. The proposed meso substrates for the enzymes, easily produced from starting materials such as cycloheptatriene, are densely funtionalized cyclic compounds. The enzymatic reactions will serve to unveil multiple chiral centers and result in compounds that should be useful building blocks for futher synthetic manipulation. Target molecules will include pancrastistatin, tetrahydrolipstatin and compounds related to amphotericin B. In order to recycle many of the enzymes of interest, an integral part of the study will involve the development of new general technology for the immobilization of enzymes based on a new polymer containing azlactone groups.