Development of Chemoenzymatic Approaches to Bioactive Molecules

生物活性分子化学酶方法的发展

• 批准号: 8922955
• 负责人: Carl Johnson
• 金额: $ 33.62万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8922955&HistoricalAwards=false
• 关键词: Development; Chemoenzymatic; Approaches; Bioactive; Molecules

The Synthetic Organic Program is supporting the research of Dr. Carl R. Johnson in the Department of Chemistry at Wayne State University. Studies designed to advance the applications of enzymes as catalysts in key steps of the synthesis of complex organic molecules will be the focus of the project. The proposed meso substrates for the enzymes, easily produced from starting materials such as cycloheptatriene, are densely funtionalized cyclic compounds. The enzymatic reactions will serve to unveil multiple chiral centers and result in compounds that should be useful building blocks for futher synthetic manipulation. Target molecules will include pancrastistatin, tetrahydrolipstatin and compounds related to amphotericin B. In order to recycle many of the enzymes of interest, an integral part of the study will involve the development of new general technology for the immobilization of enzymes based on a new polymer containing azlactone groups.

合成有机计划正在支持博士的研究。 Carl R.韦恩州立大学化学系的约翰逊 大学 研究旨在促进 酶作为复合物合成关键步骤的催化剂 有机分子将是该项目的重点。 的 提出的酶的内消旋底物，容易从 起始原料如环庚三烯， 官能化的环状化合物。 酶促反应将 用于揭示多个手性中心并产生化合物 这应该是进一步合成 操纵 靶分子将包括pancrastistatin， 四氢lipstatin和与阿替霉素B相关的化合物。 为了回收许多感兴趣的酶， 研究的一个组成部分将涉及新的发展， 固定化酶的一般技术 含有吖内酯基团的新型聚合物。