U.S.-Czech Research on DNA Interactions of Polynuclear Platinum

这个由里士满弗吉尼亚联邦大学的Nicholas Farrell和布尔诺生物物理研究所的Viktor Brabec合作的美国-捷克研究项目，对双核和三核铂配合物在DNA中引起的构象变化进行了详细的结构检查。研究人员打算制备二核和三核配合物的位点特异性DNA加合物，并系统地检查它们的结构和构象序列。结果有望产生特定DNA加合物结构的三维图像，并提高我们对DNA拓扑结构对其与铂配合物的结合模式以及特定蛋白质对其识别的影响的理解。如果成功，研究结果可能有助于提炼一类新的抗肿瘤药物。该生物化学合作研究项目通过使美国和中欧的顶尖专家在共同感兴趣和能力强的领域结合互补的人才和汇集研究资源，实现了推进科学知识的计划目标。

INT 9805552FarrellThis U.S.-Czech research project between Nicholas Farrell of Virginia Commonwealth University, Richmond, and Viktor Brabec of Institute of Biophysics, Brno, features detailed structural examination of the conformational changes induced in DNA by dinuclear and trinuclear platinum complexes. The researchers intend to prepare site-specific DNA adducts of di- and trinuclear complexes and systematically examine their structure and conformational sequences. Results are expected to produce a three dimensional picture of the structures of specific DNA adducts and to improve our understanding of the effect of DNA topology on its binding modes to platinum complexes and their recognition by specific proteins. If successful, findings may be useful in refining a new class of antitumor agents.This cooperative research project in biochemistry fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Central Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence.