POWRE: Research and Educational Enhancement at Otterbein: Effects of Surfactants Mesophase and Divalent Cations on Structures in Model Lipid Bilayers & Cell Membranes

POWRE：Otterbein 的研究和教育增强：表面活性剂中间相和二价阳离子对模型脂质双层结构的影响

• 批准号: 9806185
• 负责人: Chihae Yang
• 金额: $ 7.5万
• 依托单位: Otterbein College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9806185&HistoricalAwards=false
• 关键词: POWRE; Research; Educational; Enhancement; Otterbein

This award of the Professional Opportunities for Women in Research and Education (POWRE) program funded by the Division of Chemistry supports the research and educational activities of Dr. Chihae Yang of Otterbein College. The project aims to strengthen and expand Dr. Yang's research with colloid and surface chemistry of amphiphilic macromolecules to include biocolloid chemistry and ultimately to implement a biochemistry-related research program at Otterbein. The proposed research will develop an understanding of the influence of surfactants and certain divalent cations on the mesophase structures of model lipid bilayers and to apply this knowledge to more complex systems in order to explain the effect of these additives on cell membranes. Structural characterization will be accomplished using a variety of techniques, including XRD, NMR, IP-SANS, light scattering, and IR and fluorescence spectroscopy.The opportunity afforded through the POWRE program will enhance Dr. Yang's research potential as well as her ultimate goal of the educational mentoring of undergraduate students in both classroom and research laboratory. The proposed research will provide undergraduate students from a small liberal arts college exposure to a major research university, state-of-the-art instrumentation, and leading researchers in the field. This project not only motivates the collaboration of the PI with researchers at the Ohio State University, but also encourages collaboration between faculty members at Otterbein to pool their resources and talents for the common goal of implementing biochemical research at Otterbein.

由化学系资助的女性研究和教育专业机会（POWRE）计划的这一奖项支持Otterbein College的Chihae Yang博士的研究和教育活动。 该项目旨在加强和扩大杨博士对两亲性大分子的胶体和表面化学的研究，包括生物胶体化学，并最终在Otterbein实施生物化学相关的研究计划。 拟议中的研究将开发的表面活性剂和某些二价阳离子的模型脂质双层的中间相结构的影响的理解，并将此知识应用到更复杂的系统，以解释这些添加剂对细胞膜的影响。 结构表征将使用各种技术完成，包括XRD，NMR，IP-SANS，光散射，IR和荧光光谱。通过POWRE计划提供的机会将提高杨博士的研究潜力，以及她在课堂和研究实验室对本科生进行教育指导的最终目标。 拟议的研究将提供本科生从一个小的文科学院接触到一个主要的研究型大学，国家的最先进的仪器，并在该领域的领先研究人员。 该项目不仅激励PI与俄亥俄州州立大学研究人员的合作，还鼓励Otterbein教师之间的合作，以汇集他们的资源和人才，实现Otterbein生物化学研究的共同目标。