RUI: Mechanisms of Activity-Induced Circadian Clock Resetting

RUI：活动引起的生物钟重置机制

• 批准号: 9808866
• 负责人: Daniel Janik
• 金额: $ 24万
• 依托单位: University of Wisconsin-Eau Claire
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2004-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9808866&HistoricalAwards=false
• 关键词: RUI; Mechanisms; Activity; Induced; Circadian

LAY ABSTRACT IBN 9808866 The circadian clock that controls daily rhythms of many bodily functions and behaviors can be reset in by vigorous exercise. Whether or not the clocks reset depends on the time of day and intensity of the exercise. This project will focus on the behavioral and neural mechanisms underlying this response. Because not all individuals show the response, the first part of the project will develop criteria to predict which animals show activity-induced resetting. Next, an artificial selection study will be conducted to create a line of hamsters enriched with animals that show resetting. This enriched line will then be used to map regions of the brain that are activated during resetting. This will be followed by experiments that examine the involvement of GABA, a neurotransmitter in a part of the brain - the geniculohypothalamic tract - that has previously been implicated in activity-induced resetting. The results of this study will enhance our understanding of the process of clock resetting in the mammalian brain. Furthermore, the participation of undergraduate students in this project will provide them with valuable hands-on learning experiences that will complement and extend their standard course work.

IBN 9808866无菌摘要 控制许多身体功能和行为的日常节奏的生物钟可以通过剧烈运动重新设置。时钟是否重置取决于一天中的时间和锻炼的强度。 这个项目将集中在这种反应背后的行为和神经机制。因为不是所有的个体都表现出反应，该项目的第一部分将制定标准来预测哪些动物表现出活动诱导的重置。接下来，将进行人工选择研究，以创建一个富含显示重置的动物的仓鼠品系。然后，这条丰富的线将被用来绘制在重置过程中激活的大脑区域。随后将进行实验，检查GABA的参与，GABA是大脑一部分-膝状下丘脑束-的神经递质，以前曾参与活动诱导的重置。这项研究的结果将加强我们对哺乳动物大脑中时钟重置过程的理解。此外，本科生在这个项目的参与将为他们提供宝贵的实践学习经验，将补充和扩展他们的标准课程工作。