Novel Hydrogel Based Three-Dimensional Bridges for Nerve Regeneration

用于神经再生的新型水凝胶三维桥

• 批准号: 9809581
• 负责人: Ravi Bellamkonda
• 金额: $ 15.69万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-10-01 至 2002-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9809581&HistoricalAwards=false
• 关键词: Novel; Hydrogel; Based; Three; Dimensional

9809581 Bellamkonda The goal of the proposed research is to design novel three dimensional substrate systems based on agarose to act as bridges for the regeneration of neural tissue. The approach is based on previous work by the investigator. The goals of the research are to better understand the process of neurite extension into the agarose gels, to investigate the behavior of neurites at interfaces of gels, to develop novel delivery systems designed to deliver effector molecules that would influence the maturation and proliferation of cells, and finally to evaluate the optimized agarose based three dimensional systems in a severed sciatic nerve gap model. ***

9809581 Bellamkonda所提出的研究的目标是设计基于琼脂糖的新型三维基质系统，作为神经组织再生的桥梁。 该方法基于调查员以前的工作。 本研究的目的是更好地了解神经突延伸到琼脂糖凝胶中的过程，研究神经突在凝胶界面处的行为，开发新的递送系统，设计用于递送影响细胞成熟和增殖的效应分子，并最终在切断的坐骨神经间隙模型中评估优化的基于琼脂糖的三维系统。 ***