Gordon Research Conference on Nitric Oxide in Biochemistry and Biology to be held February of 1999 at the Harbor Towne Resort in Ventura, California

[809928]格里菲斯几十年来，人们都知道一氧化氮是燃烧的产物，是空气污染的主要成分。尽管如此，一氧化氮对生物系统的影响只受到很少的关注。对一氧化氮的兴趣在1986年随着发现一氧化氮在包括人类在内的哺乳动物体内内源性产生而升级；在随后的12年里，这一领域的研究和知识出现了爆炸式增长。由于一氧化氮是一种微小的、可自由扩散的自由基气体，它是一种最不寻常的生物介质。了解一氧化氮的生物化学和生物学不仅需要通常的酶学、生理学和药理学学科，还需要对一氧化氮化学有一个复杂的认识。尤其重要的是，具有这些不同兴趣和专业领域的科学家定期聚在一起，分享问题、见解和实验方法。由该基金支持的第三届两年一次的戈登生物化学和生物学一氧化氮研究会议满足了这一需求。会议将于1999年2月在加州文图拉举行，为期五天的会议将汇集来自全国各地和世界各地的调查人员。按照传统的戈登会议风格，参加会议的科学家将被限制在125名以内。会议将涵盖的主题包括一氧化氮的生物化学、一氧化氮合成的酶学、完整细胞中一氧化氮代谢的调控、一氧化氮细胞毒性的分子机制、氧化应激和一氧化氮的产生、一氧化氮的信号转导机制、细菌和真菌中一氧化氮的代谢。NSF基金将通过报销他们的旅费和注册费来促进初任研究者、博士后研究员和研究生的出席。

9809928 Griffith It has been known for decades that nitric oxide is a product of combustion and a major component of air pollution. Nonetheless, the effects of nitric oxide on biological systems received only modest attention. Interest in nitric oxide escalated in 1986 with the discovery that nitric oxide is produced endogenously in mammals including man; in the subsequent 12 years there has been an explosion of research and knowledge in this area. Because nitric oxide is a small, freely diffusible, free radical gas it is a most unusual biological mediator. Understanding the biochemistry and biology of nitric oxide requires not only the usual disciplines of enzymology, physiology and pharmacology, but also a sophisticated appreciation of nitric oxide chemistry. It is particularly important that scientists with these diverse interests and areas of expertise meet together periodically to share questions, insights, and experimental approaches. The third biennial Gordon Research Conference on Nitric Oxide in Biochemistry and Biology, which is supported by this grant, meets this need. The conference will be held in February, 1999, in Ventura, California, and will bring together for a five-day meeting investigators from across the country and around the world. In traditional Gordon Conference style, participation will be limited to 125 scientists. Topics to be covered at the conference include the biological chemistry of nitric oxide, the enzymology of nitric oxide synthesis, the regulation of nitric oxide metabolism in intact cells, the molecular mechanisms of nitric oxide cytotoxicity, oxidative stress and nitric oxide production, signal transduction mechanisms involving nitric oxide, and metabolism of nitric oxide in bacteria and fungi. NSF funds will be used to facilitate the attendance of beginning investigators, postdoctoral fellows, and graduate students by reimbursing their travel and registration expenses.