Poroelastic Transport of Neutral and Charged Species in Arterial Tissue

9810098西蒙，这项研究的目标是扩展研究人员发展的大动脉结构和运输耦合特性的多孔超弹性运输膨胀(PHETS)场理论。基于扩展理论的新的有限元模型将被用来分析在不同载荷条件下带电物质和中性物质在离体兔颈动脉中传输的实验结果。有了PHETS材料参数的非线性各向异性组织弹性、渗透率、扩散率、机械力-化学耦合和对流，新的模型将能够预测体内条件的结果，这些条件不容易在实验中执行，并表征血管内局部药物输送系统的作用。在去内皮化的兔颈动脉中进行的实验研究将检验荧光标记的带电和中性物质在单独的压力负载以及联合压力和流动条件下的传输。***

9810098 Simon The objective of this research is to extend porohyperelastic transport swelling (PHETS) field theories developed by the investigators for the coupled structural and transport properties of large arteries. New finite element models based on the extended theories will be implemented and used to analyze the results of experiments on the transport of charged and neutral species in excised rabbit carotid arteries under various loading conditions. With PHETS material parameters for nonlinear anisotropic tissue elasticity, permeability, diffusivity, mechano-chemical coupling, and convection thus identified from the analysis of the experimental studies, the new models will be able to predict the results of in-vivo conditions that can not readily be performed experimentally and to characterize the action of intravascular local drug delivery systems. Experimental studies in de-endothelialized rabbit carotid arteries will examine the transport of fluorescence-labeled charged and neutral species under pressure loading alone as well as combined pressure and flow conditions. ***