Poroelastic Transport of Neutral and Charged Species in Arterial Tissue

9810098 Simon本研究的目的是扩展研究人员为大动脉的耦合结构和传输特性开发的多孔超弹性传输溶胀（PHETS）场理论。 新的有限元模型的基础上扩展的理论将实施和用于分析的带电和中性物种在离体兔颈动脉在各种负荷条件下的运输实验的结果。 与PHETS材料参数的非线性各向异性组织弹性，渗透性，扩散性，机械化学耦合，对流，从而确定从实验研究的分析，新的模型将能够预测的结果，在体内的条件下，不能很容易地进行实验和表征血管内局部给药系统的行动。 在去内皮化的兔颈动脉中的实验研究将检查在单独的压力负荷以及组合的压力和流量条件下荧光标记的带电和中性物质的转运。 ***

9810098 Simon The objective of this research is to extend porohyperelastic transport swelling (PHETS) field theories developed by the investigators for the coupled structural and transport properties of large arteries. New finite element models based on the extended theories will be implemented and used to analyze the results of experiments on the transport of charged and neutral species in excised rabbit carotid arteries under various loading conditions. With PHETS material parameters for nonlinear anisotropic tissue elasticity, permeability, diffusivity, mechano-chemical coupling, and convection thus identified from the analysis of the experimental studies, the new models will be able to predict the results of in-vivo conditions that can not readily be performed experimentally and to characterize the action of intravascular local drug delivery systems. Experimental studies in de-endothelialized rabbit carotid arteries will examine the transport of fluorescence-labeled charged and neutral species under pressure loading alone as well as combined pressure and flow conditions. ***