Poroelastic Transport of Neutral and Charged Species in Arterial Tissue

9810098 Simon本研究的目的是扩展研究人员关于大动脉耦合结构和输运性质的多孔超弹性输运膨胀（PHETS）场理论。基于扩展理论的新有限元模型将用于分析不同载荷条件下兔颈动脉内带电和中性物质的输运实验结果。通过对实验研究的分析，确定了PHETS材料的非线性各向异性组织弹性、渗透率、扩散率、机械-化学耦合和对流等参数，新模型将能够预测体内条件的结果，而这些条件在实验中是不容易实现的，并能够表征血管内局部药物传递系统的作用。在去内皮化的兔颈动脉中进行的实验研究将检查荧光标记的带电和中性物质在单独压力载荷以及压力和流量联合条件下的运输。＊＊＊

9810098 Simon The objective of this research is to extend porohyperelastic transport swelling (PHETS) field theories developed by the investigators for the coupled structural and transport properties of large arteries. New finite element models based on the extended theories will be implemented and used to analyze the results of experiments on the transport of charged and neutral species in excised rabbit carotid arteries under various loading conditions. With PHETS material parameters for nonlinear anisotropic tissue elasticity, permeability, diffusivity, mechano-chemical coupling, and convection thus identified from the analysis of the experimental studies, the new models will be able to predict the results of in-vivo conditions that can not readily be performed experimentally and to characterize the action of intravascular local drug delivery systems. Experimental studies in de-endothelialized rabbit carotid arteries will examine the transport of fluorescence-labeled charged and neutral species under pressure loading alone as well as combined pressure and flow conditions. ***