Finite Strain, Poroelastic Model for Large Arteries

这项研究将使用多孔超弹性模型来研究动脉壁内的液体运输，特别是脂质运输。该模型将包括与历史相关的有限变形、应力和跨壁组织液流。将使用实验研究来验证和/或修改该模型。这项研究将开发的模型是朝着实现全面的动脉壁模型迈出的一步，该模型将有助于解释动脉粥样硬化的病因。这一结果可能会对动脉血管假体的设计产生影响，并对包括软骨和皮肤在内的其他组织的研究有所帮助。

This study will use a porohyperelastic model to study fluid transport, and in particular lipid transport, within the arterial wall. This model will include history-dependent finite deformation, stress, and transmural tissue fluid flow. Experimental studies will be used to verify and/or modify the model. The model that will be developed in this study is a step towards achieving a comprehensive arterial wall model that would help explain the etiology of atherosclerosis. The results could have an impact on the design of arterial vascular prostheses and be useful in the study of other tissues including cartilage and skin.