OXPL - Molecular level physiology and pathology of oxidized phospholipids

OXPL - 氧化磷脂的分子水平生理学和病理学

• 批准号: 128019854
• 负责人: Professor Dr. Thorsten Hugel
• 金额: --
• 依托单位: Institut für Physikalische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/128019854?language=en
• 关键词: OXPL; Molecular; level; physiology; pathology

Oxidized phospholipids (oxPL) are now known to be involved in several pathological conditions, such as atherosclerosis, inflammation, infection, cancer, type 2 diabetes, and Alzheimer’s disease. Furthermore, phospholipid oxidation appears to be generically involved in apoptosis. However, a coherent overall view of the causalities and mechanisms behind these conditions is lacking, mainly because of insufficient understanding of the occurring processes on a cellular as well as a molecular level. The OXPL consortium represents a highly focussed, integrated interdisciplinary approach of European research laboratories already active in this now rapidly emerging area in biological chemistry, together with additional skills brought into the project by groups representing state-of-the-art expertise in method and high resolution instrumentation development for the characterization of biomolecules, their interactions in biomembranes, and localization in cells. More specifically, this CRP combines leading edge expertises on membrane biophysics, from modern MD simulations to a range of experimental techniques (ellipsometry, Langmuir troughs, FCS, AFM, NMR), all the way to protein folding, molecular cell biology, imaging, chemical biology, and lipidomics analyses. The project will pave the way to the development of improved diagnostics, therapies and preventive measures to combat the above diseases, and will take European research to the leading edge in this rapidly emerging and important area.

目前已知氧化磷脂 (oxPL) 与多种病理状况有关，例如动脉粥样硬化、炎症、感染、癌症、2 型糖尿病和阿尔茨海默病。此外，磷脂氧化似乎普遍参与细胞凋亡。然而，缺乏对这些条件背后的因果关系和机制的连贯整体看法，主要是因为对细胞和分子水平上发生的过程了解不足。 OXPL 联盟代表了欧洲研究实验室高度集中、综合的跨学科方法，这些实验室已经活跃在生物化学这一快速新兴领域，同时还代表了代表生物分子表征、生物膜中相互作用和细胞定位的方法和高分辨率仪器开发方面最先进专业知识的团体为该项目带来的额外技能。更具体地说，该 CRP 结合了膜生物物理学的前沿专业知识，从现代 MD 模拟到一系列实验技术（椭圆光度法、朗缪尔槽、FCS、AFM、NMR），一直到蛋白质折叠、分子细胞生物学、成像、化学生物学和脂质组学分析。该项目将为开发改进的诊断、治疗和预防措施以对抗上述疾病铺平道路，并将使欧洲研究在这一迅速新兴的重要领域处于领先地位。