U.S.-India Cooperative Research: Engineering of Oxygen Affinity of a Unique Bacterial Hemoglobin from Vitreoscilla and Studies on Cellular Physiology & Biotechnological Proces

9811595 Webster描述：该奖项是针对分子生物化学领域的联合研究，题为“美印合作研究：玻璃颤菌独特细菌血红蛋白的氧亲和力工程及其在细胞生理学和生物技术过程中的作用和意义研究”。合作者是伊利诺伊大学的p.s. Webster和Stark，以及昌迪加尔微生物技术研究所的共同p.s. Dikshit。他们将进行实验，以表征和了解玻璃震菌的“血红蛋白”的生化功能，以及当通过基因工程将其引入无血红蛋白的细菌时，它如何改变其新宿主代谢的生化途径。研究范围：本研究具有重要的科学价值和实用价值，对基础知识有一定的补充作用。此次合作将利用两组研究人员的互补专业知识：美国方面的蛋白质生物化学和物理化学，印度方面的重组DNA技术，双方都有明显的好处。＊＊＊

9811595 Webster Description: This award is for joint research in molecular biochemistry entitled US-India Cooperative Research: Engineering of Oxygen Affinity of a Unique Bacterial Hemoglobin from Vitreoscilla and Studies on Its Role and Implications on Cellular Physiology and Biotechnological Processes. The collaborators are PIs Webster and Stark of Illinois University and co-PI Dikshit of the Institute of Microbial Technology, Chandigarh. They will perform experiments to characterize and obtain understanding on the biochemical function of the "hemoglobin" of the bacterium Vitreoscilla and how, when introduced into a hemoglobin-less bacterium by genetic engineering, it changes the biochemical pathways of its new host's metabolism. Scope: This research has great scientific and practical value, and will add to fundamental knowledge. The collaboration will exploit the complementary expertise of the two groups of investigators: biochemistry and physical chemistry of proteins on the US side and recombinant DNA technology on the Indian side, with obvious benefit to both. ***