Self-assembly of hierarchical magnetic nano- to microstructures: biogenic and biomimetic synthesis of magnetite chains

分层磁性纳米到微米结构的自组装：磁铁矿链的生物成因和仿生合成

• 批准号: 128306620
• 负责人: Dr. Damien Faivre
• 金额: --
• 依托单位: Lehrstuhl für Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/128306620?language=en
• 关键词: Self; assembly; hierarchical; magnetic; nano

Magnetotactic bacteria form intracellular chains of magnetosomes, which display a hierarchically ordered nano- and microstructure over several levels, up to the magnetic control of coordinated alignment and motility of entire populations of cells. The bacterial magnetic structures are formed by biomineralization from membrane-enveloped, biomineralized magnetic nanocrystals, which in turn by self-assembly align into more complex structures. Bacterial magnetosome formation is under strict biological control, which is associated with unprecedented material properties. However, despite of considerable efforts by material sciences, the resulting complex magnetic structures have not been replicated yet by conventional technological approaches.In this project, we suggest a biomimetic approach for the synthesis of hierarchically structured magnetic nanomaterials, which is inspired by the bacterial system. After previous identification and characterization of molecular determinants and building blocks, we now aim to reconstitute in vitro the assembly of magnetic nanocrystals purified from bacteria. In particular, this will involve the bacterial proteins MamK and MamJ which are known to collectively form the cytoskeletal network controlling alignment of magnetosome chains in vivo. Next, biological constituents will be partially substituted and combined with novel material components, such as modified polymeric structures and biomimetic magnetic nanoparticles. Ultimately, we will apply the principles of biological assembly to design hierarchically ordered two- and three-dimensional nano- and microstructures with novel and tailored mechanical, physico-chemical, and magnetic material characteristics.

趋磁细菌形成磁小体的细胞内链，其在几个水平上显示分级有序的纳米和微观结构，直到整个细胞群体的协调排列和运动的磁性控制。细菌磁性结构是由膜包裹的生物矿化的磁性纳米晶体通过生物矿化形成的，这些纳米晶体又通过自组装排列成更复杂的结构。细菌磁小体的形成受到严格的生物控制，这与前所未有的材料特性有关。然而，尽管材料科学做出了相当大的努力，但由此产生的复杂磁性结构还没有被传统的技术方法复制。在本项目中，我们提出了一种仿生方法来合成具有分级结构的磁性纳米材料，这是受到细菌系统的启发。在先前的分子决定簇和构建块的鉴定和表征之后，我们现在的目标是在体外重建从细菌中纯化的磁性纳米晶体的组装。特别地，这将涉及已知共同形成控制体内磁小体链对齐的细胞骨架网络的细菌蛋白MamK和MamJ。接下来，生物成分将被部分取代，并与新的材料成分结合，如改性聚合物结构和仿生磁性纳米颗粒。最终，我们将应用生物组装的原理来设计具有新颖和定制的机械，物理化学和磁性材料特性的分层有序的二维和三维纳米和微观结构。