Interaction Between Multiple Memory System in the Mammalian Brain: Preliminary Studies

简单摘要 哺乳动物脑内多种记忆系统的相互作用 IBN9813587 行为神经科学领域已经开始认识到，一个简单的行为反应的控制和方向可能不是单一心理过程的结果，但可能反映了不止一个这样的过程的参与，因此，涉及一个以上的潜在神经系统。当一个以上的神经系统参与指导和指导行为的经验的基础上，有三种可能的方式，这些系统可以在逻辑上相互作用，在学习的情况下：A）它们可以以并行冗余方式独立且同时地操作，B）一个系统可以支配其他系统以控制行为，或C）多个系统可能需要协作以解决给定任务。拟议的实验的目标是收集这些相互作用的神经化学基础上的初步数据，以开发复杂的认知控制行为的体内动物模型系统。 拟议的初步研究利用以前使用的永久性和可逆性损伤方法的行为任务，重点放在第二种逻辑形式的相互作用，一个神经系统占主导地位的其他（S）。为了研究特定的神经结构在多个记忆系统之间的功能和神经化学关系中的作用，实验采用了两种互补的技术。第一种是与高压液相色谱（HPLC）结合的体内微透析，以测量对学习和记忆重要的结构中的神经递质释放（即，海马和背侧纹状体）。第二种是特定部位的直接大脑注射，以改变学习和行为过程中特定神经化学系统的活动。这些发现有望为理解特定神经系统对行为的控制分配机制提供基础。未来研究的目标是进一步描述和分类多个记忆系统之间相互作用的神经解剖学和神经化学基础。更好地理解这些相互作用对于开发正在进行的复杂控制和行为方向的准确模型是必要的。这种精细的模型将对从基础神经生物学和神经行为学到复杂计算神经网络设计的其他研究领域具有价值。

LAY ABSTRACT Interaction between Multiple Memory Systems in the Mammalian Brain IBN9813587 The field of behavioral neuroscience has begun to appreciate that the control and direction of a presumably simple behavioral response may not be the result of a single psychological process, but may reflect the involvement of more than one such process and therefore, the involvement of more than one underlying neural system. When more than one neural system is involved in guiding and directing behavior on the basis of experience, there are three possible ways that these systems can logically interact during a learning situation: A) they may operate independently and simultaneously, in a parallel redundant fashion, B) one system may predominate over the other(s) to control behavior, or C) multiple systems may need to cooperate in order to solve a given task. The goal of the proposed experiments is to collect preliminary data on the neurochemical basis of these interactions in order to develop in vivo animal model systems for the complex cognitive control of behavior. The proposed preliminary research utilizes behavioral tasks that have been used previously with permanent and reversible lesion methodologies to focus on the second logical form of interaction, one neural system predominating over the other(s). To investigate the roles of specific neural structures in the functional and neurochemical relationships among multiple memory systems, the experiments employ two complementary techniques. The first is in vivo microdialysis coupled with high pressure liquid chromatography (HPLC) to measure neurotransmitter release in structures important for learning and memory (i.e., hippocampus and dorsal striatum) during ongoing learning and behavior. The second is site-specific direct brain injections to alter the activity in specific neurochemical systems during learning and behavior. The findings are anticipated to provide the basis for understanding the mechanisms und erlying the allocation of control over behavior by specific neural systems. The aim of future studies is to describe and categorize further the neuroanatomical and neurochemical bases of interactions among multiple memory systems. Greater understanding of these interactions is necessary to develop accurate models of the ongoing complex control and direction of behavior. Such refined models would be of value to other fields of inquiry ranging from the basic neurobiology and neuroethology to the design of complex computational neural networks.