RF Equipment for Hyperpolarized 129Xe and 3He MRI at Low Field

9813777 Albert本提案的目的是扩展由General Electric Medical Systems捐赠给研究者的低场磁共振成像（MRI）系统的工作频率。 这需要采集射频（RF）组件，以将工作频率扩展到2-10 MHz范围。 这可能使研究人员及其合作者最近发明的超极化惰性气体MRI能够用于迄今为止对传统质子MR造成困难的人体结构和功能的成像和光谱学。潜在应用包括：（1）肺部和肺部气体成像（用于肺气肿诊断和呼吸功能研究），（2）脑内脂质结构的成像（用于多发性硬化症的诊断和分期以及脑功能的研究），以及3）更好地测量流向组织的血流量（对中风和缺血诊断以及对脑和心肺功能的研究很重要）。*

9813777AlbertThe objective of this proposal is to extend the operating frequency of a low-field magnetic resonance imaging (MRI) system being donated to the investigator by General Electric Medical Systems. This requires the acquisition of radio frequency (RF) components to extend the operating frequency to cover the 2-10 MHz range. This may enable the hyperpolarized noble gas MRI, recently invented by the investigator and his collaborators, to be used for the imaging and spectroscopy of human body structures and functions that have hitherto posed difficulties for conventional proton MR. The potential applications include: (1) lung and lung-gas imaging (for diagnosis of emphysema and studies of respiratory function), (2) the imaging of lipid structures in the brain (for the diagnosis and staging of multiple sclerosis and in research on brain function), and 3) better measurement of blood flow to tissue (important for stroke and ischemia diagnosis, and also for research in brain and cardiopulmonary function).***