Gordon Research Conference on Mammalian DNA Repair, February 7-12, 1999, in Ventura, California

Hanawalt 该奖项将帮助不太知名的科学家参加 1999 年 2 月 7 日至 2 月 12 日在加利福尼亚州文图拉举行的第七届戈登哺乳动物 DNA 修复研究会议。选定的演讲者是该领域和相关细胞过程的当前领导者。除了为这些专家提供一个展示最新成果和想法的论坛外，会议还将通过全体会议和海报促进所有与会者之间的广泛互动。为了激发全体会议后的辩论，选定的海报展示者（通常是学生和年轻科学家）将有机会在简短的演讲中强调他们的研究成果，与会者将从全球范围内的大学、研究机构以及政府和工业研究实验室中选出。 这些会议将定义正在出现令人兴奋的新信息但专家可能存在分歧的领域。会议主题包括：细胞核和线粒体内源性损伤的修复；跨损伤合成和错配修复； DNA修复酶结构和底物相互作用；核苷酸切除修复-转录的作用；碱基切除修复——与其他途径重叠；诱导反应和细胞周期检查点；总之，本次会议将研究 DNA 修复作为基因组监测的关键组成部分，这对于哺乳动物细胞的整体完整性和功能至关重要。最近的发现使 DNA 修复在衰老、环境健康和发育生物学领域的基础研究中占据了关键地位。希望本次会议的激烈讨论中能够突出最有前途和令人兴奋的研究途径。

Hanawalt This award will help enable less-established scientists to participate in the seventh bi-annual Gordon Research Conference on Mammalian DNA Repair in Ventura, California, Feb. 7 - Feb. 12, 1999. The selected speakers are current leaders in this area and related cellular processes. Besides providing a forum for these experts to present their most recent results and ideas, the conference will facilitate wide-ranging interactions among all attendees through Plenary Discussion Sessions and at posters. To stimulate debate following the plenary talks, selected poster presenters (generally students and younger scientists) will be given the opportunity to highlight their research results in short presentations, The attendees will be chosen globally from universities, research institutes, and government and industrial research labs. The sessions will define areas in which exciting new information is emerging but in which experts may disagree. The session topics include the following: repair of endogenous damage in nuclei and mitochondria; translesion synthesis and repair of mismatches; DNA repair enzyme structure and substrate interactions; nucleotide excision repair - the role of transcription; base excision repair - overlap with other pathways; inducible responses and cell cycle checkpoints; and cellular localization of repair and effects of bound proteins.In summary, this conference will examine DNA repair as a key component in the genomic surveillance that is so crucial to the overall integrity and function of mammalian cells. Recent discoveries have catapulted DNA repair into a pivotal position in fundamental research in the fields of aging, environmental health, and developmental biology. It is hoped that the most promising and exciting avenues of research will be highlighted in robust discussions at this conference.