Gordon Research Conference on Mammalian DNA Repair, February 7-12, 1999, in Ventura, California

哈纳瓦尔特 该奖项将有助于使不太成熟的科学家参加第七届两年一度的戈登哺乳动物DNA修复研究会议在文图拉，加州，1999年2月7日至2月12日。 选定的发言者是目前在这一领域和相关的细胞过程的领导者。除了为这些专家提供一个论坛来展示他们的最新成果和想法外，会议还将通过全体讨论会和海报促进所有与会者之间的广泛互动。为了激发全体会议后的辩论，选定的海报演讲者（通常是学生和年轻科学家）将有机会在简短的演讲中突出他们的研究成果，与会者将从全球大学，研究机构，政府和工业研究实验室中选出。 这些会议将确定哪些领域正在出现令人兴奋的新信息，但专家们可能不同意。会议主题包括以下内容：细胞核和线粒体内源性损伤的修复;跨损伤合成和错配修复; DNA修复酶结构和底物相互作用;核苷酸切除修复-转录的作用;碱基切除修复-与其他途径重叠;诱导反应和细胞周期检查点;总之，本次会议将研究DNA修复作为基因组监测的关键组成部分，对哺乳动物细胞的整体完整性和功能至关重要。最近的发现使DNA修复在衰老，环境健康和发育生物学领域的基础研究中占据了关键地位。希望最有前途和最令人兴奋的研究途径将在本次会议的热烈讨论中得到强调。

Hanawalt This award will help enable less-established scientists to participate in the seventh bi-annual Gordon Research Conference on Mammalian DNA Repair in Ventura, California, Feb. 7 - Feb. 12, 1999. The selected speakers are current leaders in this area and related cellular processes. Besides providing a forum for these experts to present their most recent results and ideas, the conference will facilitate wide-ranging interactions among all attendees through Plenary Discussion Sessions and at posters. To stimulate debate following the plenary talks, selected poster presenters (generally students and younger scientists) will be given the opportunity to highlight their research results in short presentations, The attendees will be chosen globally from universities, research institutes, and government and industrial research labs. The sessions will define areas in which exciting new information is emerging but in which experts may disagree. The session topics include the following: repair of endogenous damage in nuclei and mitochondria; translesion synthesis and repair of mismatches; DNA repair enzyme structure and substrate interactions; nucleotide excision repair - the role of transcription; base excision repair - overlap with other pathways; inducible responses and cell cycle checkpoints; and cellular localization of repair and effects of bound proteins.In summary, this conference will examine DNA repair as a key component in the genomic surveillance that is so crucial to the overall integrity and function of mammalian cells. Recent discoveries have catapulted DNA repair into a pivotal position in fundamental research in the fields of aging, environmental health, and developmental biology. It is hoped that the most promising and exciting avenues of research will be highlighted in robust discussions at this conference.