Gordon Research Conference on Mammalian DNA Repair, February 7-12, 1999, in Ventura, California

这个奖项将帮助那些不太知名的科学家参加1999年2月7日至2月12日在加州文图拉举行的第七届戈登哺乳动物DNA修复研究会议。所选的演讲者是该领域和相关细胞过程的当前领导者。除了为这些专家提供一个展示他们最新成果和想法的论坛外，会议还将通过全体讨论会议和海报活动促进所有与会者之间的广泛互动。为了在全体会议之后激发辩论，选定的海报演讲者（一般是学生和年轻科学家）将有机会在简短的演讲中突出他们的研究成果。与会者将从全球大学、研究机构、政府和工业研究实验室中选出。会议将界定那些令人兴奋的新信息正在出现，但专家们可能不同意的领域。会议主题包括：细胞核和线粒体内源性损伤的修复；翻译合成与错配修复；DNA修复酶结构与底物相互作用；核苷酸切除修复-转录的作用碱基切除修复-与其他通路重叠；诱导应答和细胞周期检查点；以及细胞定位修复和结合蛋白的作用。总之，本次会议将研究DNA修复作为基因组监测的关键组成部分，这对哺乳动物细胞的整体完整性和功能至关重要。最近的发现使DNA修复在衰老、环境健康和发育生物学等领域的基础研究中占据了举足轻重的地位。希望在本次会议的热烈讨论中突出最有前途和最令人兴奋的研究途径。

Hanawalt This award will help enable less-established scientists to participate in the seventh bi-annual Gordon Research Conference on Mammalian DNA Repair in Ventura, California, Feb. 7 - Feb. 12, 1999. The selected speakers are current leaders in this area and related cellular processes. Besides providing a forum for these experts to present their most recent results and ideas, the conference will facilitate wide-ranging interactions among all attendees through Plenary Discussion Sessions and at posters. To stimulate debate following the plenary talks, selected poster presenters (generally students and younger scientists) will be given the opportunity to highlight their research results in short presentations, The attendees will be chosen globally from universities, research institutes, and government and industrial research labs. The sessions will define areas in which exciting new information is emerging but in which experts may disagree. The session topics include the following: repair of endogenous damage in nuclei and mitochondria; translesion synthesis and repair of mismatches; DNA repair enzyme structure and substrate interactions; nucleotide excision repair - the role of transcription; base excision repair - overlap with other pathways; inducible responses and cell cycle checkpoints; and cellular localization of repair and effects of bound proteins.In summary, this conference will examine DNA repair as a key component in the genomic surveillance that is so crucial to the overall integrity and function of mammalian cells. Recent discoveries have catapulted DNA repair into a pivotal position in fundamental research in the fields of aging, environmental health, and developmental biology. It is hoped that the most promising and exciting avenues of research will be highlighted in robust discussions at this conference.