POWRE: Exploring the Potential of Non-natural, Sequence-Specific Polymers to Adopt Biomimetic Folded Structures

POWRE：探索非天然序列特异性聚合物采用仿生折叠结构的潜力

• 批准号: 9870386
• 负责人: Annelise Barron
• 金额: $ 7.5万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9870386&HistoricalAwards=false
• 关键词: POWRE; Exploring; Potential; Non; natural

9870386 Barron This POWRE proposal is from a very new educator and one who could profit substantially from an award. the research involves the synthesis and evaluation of a novel class of peptides where the normal alkyl chain attached to the alpha-carbon is instead attached to the amide nitrogen. The synthesis of these amino acids is easier than conventional amino acids, a broader range of these glycine derivitives is possible, and the resultant polymers are more resistant to enzymatic hydrolysis. The primary emphasis will be on developing folding rules for these natural protein mimics. The ease of synthesis will facilitate the study. The new class of polypeptoids has interesting potential applications as biomaterials. ***

9870386巴伦这个POWRE提案来自一个非常新的教育家和一个谁可以从一个奖项中获益匪浅。 该研究涉及合成和评价一类新的肽，其中连接到α-碳的正烷基链代替连接到酰胺氮。 这些氨基酸的合成比常规氨基酸更容易，这些甘氨酸衍生物的范围更广是可能的，并且所得聚合物对酶水解更具抗性。 主要的重点将是开发这些天然蛋白质模拟物的折叠规则。 易于综合将有助于研究。 这类新的类多肽作为生物材料具有有趣的潜在应用。 ***