POWRE: Exploring the Potential of Non-natural, Sequence-Specific Polymers to Adopt Biomimetic Folded Structures

9870386 Barron这个power提案来自一个非常新的教育家，他可以从一个奖项中获益良多。该研究涉及合成和评价一类新的肽，其中连接到α -碳的正常烷基链被连接到酰胺氮上。这些氨基酸的合成比传统的氨基酸更容易，这些甘氨酸衍生物的范围更广，所得到的聚合物更耐酶水解。主要的重点将是开发这些天然蛋白质模拟物的折叠规则。易于合成将有利于研究。这类新的多肽作为生物材料具有有趣的潜在应用前景。＊＊＊

9870386 Barron This POWRE proposal is from a very new educator and one who could profit substantially from an award. the research involves the synthesis and evaluation of a novel class of peptides where the normal alkyl chain attached to the alpha-carbon is instead attached to the amide nitrogen. The synthesis of these amino acids is easier than conventional amino acids, a broader range of these glycine derivitives is possible, and the resultant polymers are more resistant to enzymatic hydrolysis. The primary emphasis will be on developing folding rules for these natural protein mimics. The ease of synthesis will facilitate the study. The new class of polypeptoids has interesting potential applications as biomaterials. ***