POWRE: Exploring the Potential of Non-natural, Sequence-Specific Polymers to Adopt Biomimetic Folded Structures

9870386巴伦这份POWRE提案出自一位非常新的教育家之手，他可能会从一个奖项中获利良多。这项研究涉及一类新型多肽的合成和评价，其中连接到α-碳的正构烷基链改为连接到酰胺氮。这些氨基酸的合成比传统氨基酸更容易，这些甘氨酸衍生物的范围更广，生成的聚合物更耐酶解。主要的重点将是为这些天然蛋白质模拟物开发折叠规则。合成的简便性将有助于研究。这类新的多肽具有作为生物材料的有趣的潜在应用。***

9870386 Barron This POWRE proposal is from a very new educator and one who could profit substantially from an award. the research involves the synthesis and evaluation of a novel class of peptides where the normal alkyl chain attached to the alpha-carbon is instead attached to the amide nitrogen. The synthesis of these amino acids is easier than conventional amino acids, a broader range of these glycine derivitives is possible, and the resultant polymers are more resistant to enzymatic hydrolysis. The primary emphasis will be on developing folding rules for these natural protein mimics. The ease of synthesis will facilitate the study. The new class of polypeptoids has interesting potential applications as biomaterials. ***