Integration of Optical Spectroscopy and Optical Coherence Tomography: Increased Contrast to Recognize Early Ovarian Cancers

光谱学和光学相干断层扫描的整合：增加对比度以识别早期卵巢癌

• 批准号: 9872829
• 负责人: Rebecca Richards-Kortum
• 金额: $ 56.49万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9872829&HistoricalAwards=false
• 关键词: Integration; Optical; Spectroscopy; Coherence; Tomography

9872829Richards-KortumThe objective of this research is to develop new knowledge and technologies which integrate the advantages of optical coherence tomographic (OCT) imaging and optical spectroscopy. The aim is to enable high-contrast, molecular-specific optical imaging of early tumors in epithelial tissues. This will require the development of new biological models to allow rigorous testing of these concepts. Also, the knowledge gained from these models will be used to develop an optical system to address the clinically significant problem of ovarian cancer. The completion of these objectives will require: (1) fundamental advances in the understanding of the cellular basis of light scattering and how it can be manipulated with extrinsic agents, (2) technology development for simultaneous imaging and spectroscopy, and (3) development of molecular contrast agents and tools to test tools and developments.***

9872829Richards-Kortum这项研究的目标是开发新的知识和技术，整合光学相干断层扫描（OCT）成像和光学光谱学的优势。 目的是实现上皮组织中早期肿瘤的高对比度、分子特异性光学成像。 这将需要开发新的生物模型来严格测试这些概念。 此外，从这些模型中获得的知识将用于开发光学系统，以解决卵巢癌的临床重大问题。 完成这些目标将需要：(1) 在理解光散射的细胞基础以及如何用外在试剂操纵光散射方面取得根本进展，(2) 同步成像和光谱学的技术开发，以及 (3) 开发分子造影剂和工具来测试工具和开发。***