SFB 670: Cell-Autonomous Immunity

SFB 670：细胞自主免疫

• 批准号: 13123509
• 金额: --
• 依托单位: Universität zu Köln
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/13123509?language=en
• 关键词: SFB; 670; Cell; Autonomous; Immunity

The response of an organism to pathogens proceeds in several steps, beginning with the natural barriers, e.g., the membrane of a plant cell or the skin of the mammalia, followed by the elements of the innate immunity, which enable an early defence reaction. The initial processing of the pathogen non-self antigens in somatic cells as well as the spatiotemporally concerted defence reaction including various elements of the innate immunity normally set the course for a coordinated and well-balanced adaptive immune response.

生物体对病原体的反应分几个步骤进行，首先是天然屏障，例如植物细胞的膜或哺乳动物的皮肤，然后是先天免疫的元素，这使得早期的防御反应成为可能。体细胞对病原体非自身抗原的初始处理，以及包括先天免疫各要素在内的时空协调一致的防御反应，通常为协调和平衡的适应性免疫反应奠定了基础。

项目成果

NLR functions beyond pathogen recognition

• DOI: 10.1038/ni.1985
• 发表时间: 2011-02-01
• 期刊: NATURE IMMUNOLOGY
• 影响因子: 30.5
• 作者: Kufer, Thomas A.;Sansonetti, Philippe J.
• 通讯作者: Sansonetti, Philippe J.

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

• DOI: 10.1038/nature10273
• 发表时间: 2011-09-15
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Welz, Patrick-Simon;Wullaert, Andy;Pasparakis, Manolis
• 通讯作者: Pasparakis, Manolis

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

• DOI: 10.1038/ni.1824
• 发表时间: 2010-01-01
• 期刊: NATURE IMMUNOLOGY
• 影响因子: 30.5
• 作者: Poeck, Hendrik;Bscheider, Michael;Ruland, Juergen
• 通讯作者: Ruland, Juergen

Co-option of a default secretory pathway for plant immune responses

• DOI: 10.1038/nature06545
• 发表时间: 2008-02-14
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Kwon, Chian;Neu, Christina;Schulze-Lefert, Paul
• 通讯作者: Schulze-Lefert, Paul

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

• DOI: 10.1038/nature08206
• 发表时间: 2009-08-27
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Yazdanpanah, Benjamin;Wiegmann, Katja;Kroenke, Martin
• 通讯作者: Kroenke, Martin