CAREER: Effect of Pretreatment on Inactivation of Cryptosporidium in Natural Waters

职业：预处理对天然水中隐孢子虫灭活的影响

• 批准号: 9875580
• 负责人: gregory harrington
• 金额: $ 23.5万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9875580&HistoricalAwards=false
• 关键词: CAREER; Effect; Pretreatment; Inactivation; Cryptosporidium

9875580 Harrington The objective of this project is to investigate the influence of water treatment processes that reduce concentrations of disinfectant demanding substances such as natural organic matter on the effectiveness of disinfectants such as ozone and chlorine for inactivation of cryptosporidium species of pathogenic significance in water. The investigator plans on using completely mixed flow-through reactors to evaluate inactivation of cryptosporidium oocysts as a step toward development of mathematical models of the inactivation processes that can be used in engineering design of water treatment processes. The research will be conducted in cooperation with the Wisconsin State Laboratory of Hygiene, which will provide the cryptosporidium species used and will perform determinations of viability. The combined vital dye/flow cytometry approach to be used will permit a larger matrix of experiments than would be possible with other alternatives such as observartions of animal infectivity. The proposal leading to this award was submitted in response to the Faculty Early Career Development (CAREER) Program which emphasizes combining discovery of new knowledge with inspired teaching and enthusiastic learning. the research component of this project is expected to provide knowledge that can be applied in engineering design of processes and systems to inactivate cryptosporidium species from water supplies. The educational component is expected to provide undergraduate and graduate students with access to techniques for study of microbial inactivation processes for water treatment of significance in environmental engineering practice. The investigator's private-sector experience in consulting practice is expected to provide students with practical experiences in relating results of research to utility in engineering practice, in fostering creative thinking and emphasizing communication skills. ***

9875580哈灵顿本项目的目的是调查水处理工艺的影响，这些工艺降低了消毒剂需求物质（如天然有机物）的浓度，对臭氧和氯等消毒剂灭活水中具有致病意义的隐孢子虫的有效性产生了影响。 研究人员计划使用完全混合的流通式反应器来评估隐孢子虫卵囊的灭活，作为开发灭活过程数学模型的一步，该模型可用于水处理过程的工程设计。 这项研究将与威斯康星州卫生实验室合作进行，该实验室将提供所用的隐孢子虫物种，并将进行活力测定。 与其他替代方法（如观察动物感染性）相比，使用联合活体染料/流式细胞术方法将允许更大的实验矩阵。 该奖项的提案是为了响应教师早期职业发展（CAREER）计划而提交的，该计划强调将新知识的发现与启发式教学和热情学习相结合。 该项目的研究部分预计将提供可用于工程设计过程和系统的知识，以消除供水中的隐孢子虫物种。 教育部分预计将为本科生和研究生提供获得技术的研究微生物灭活过程的水处理的意义在环境工程实践。 调查员在咨询实践中的私营部门经验预计将为学生提供在工程实践中将研究成果与实用程序相关联的实践经验，培养创造性思维并强调沟通技巧。 ***