Self Assembly in Lipid and Polymeric Systems

脂质和聚合物系统中的自组装

• 批准号: 9876864
• 负责人: Michael Schick
• 金额: $ 27.9万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9876864&HistoricalAwards=false
• 关键词: Self; Assembly; Lipid; Polymeric; Systems

9876864SchickThis awards supports the theoretical study of several problems involving the self-assembly of complex materials, with particular emphasis on biological lipids and diblock copolymers. This project will focus on five topics: (1) a self-consistent model for the dependence of a lamellar-like phase and an inverted hexagonal phase of DNA and cationic lipid complexes on lipid concentrations; (2) a study of two proposed mechanisms to make non-viral DNA transfection more efficient; (3) the lamellar to hexagonal transition in a model mixture of lamellar and non-lamellar forming lipids with a model study of the intermediates between the two phases; (4) a related study of these intermediates using mixed real-reciprocal space methods; and, (5) a study of the surface phases of diblock copolymers as a function of copolymer architecture.%%%This awards supports the theoretical study of several problems involving the self-assembly of complex materials, with particular emphasis on biological lipids and diblock copolymers. The study of biological lipids has application to the study of non-viral DNA transfection-a technique for delivering DNA to cells by enclosing it in liposomes, but with variable efficiency for reasons that are not well understood. A second aspect of the project will focus on understanding how technologically important surface phases in diblock compolymers vary as a function of the copolymer architecture. ***

9876864Schick 该奖项支持涉及复杂材料自组装的几个问题的理论研究，特别强调生物脂质和二嵌段共聚物。 该项目将重点关注五个主题：（1）DNA和阳离子脂质复合物的层状相和倒六边形相对脂质浓度依赖性的自洽模型； (2) 研究两种提出的使非病毒DNA转染更有效的机制； (3) 层状和非层状形成脂质的模型混合物中的层状到六边形的转变，并对两相之间的中间体进行模型研究； (4) 使用混合实数倒易空间方法对这些中间体进行相关研究； (5) 作为共聚物结构函数的二嵌段共聚物的表面相的研究。%%%该奖项支持涉及复杂材料自组装的几个问题的理论研究，特别强调生物脂质和二嵌段共聚物。 生物脂质的研究可应用于非病毒 DNA 转染的研究，这是一种通过将 DNA 封装在脂质体中将 DNA 递送至细胞的技术，但由于尚不清楚的原因，其效率各不相同。 该项目的第二个方面将侧重于了解二嵌段共聚物中技术上重要的表面相如何随着共聚物结构的变化而变化。 ***