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Nanostructured Self-Assembly of Bio-Derived and Bio-Inspired Lipid-Based Amphiphiles

生物衍生和生物启发的脂质两亲物的纳米结构自组装

基本信息

批准号：
EP/V053396/1
负责人：
Ian Hamley
金额：
$ 174.6万
依托单位：
University of Reading
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FV053396%2F1
关键词：
Nanostructured Self Assembly Bio Derived

项目摘要

Nanomaterials are materials with features with a size of a few nanometres, thousands of times smaller than the width of a human hair. They are of huge interest as innovative advanced materials with applications in filtration since they can capture very small particles such as bacteria and viruses. In addition, the activity of catalysts is greatly increased for very small particles, as for example in engine catalytic convertors. Silicon chips used in the latest generation of laptops, computers and smart-phones rely on increasing the number of transistors on the chips, which is done by decreasing the size of the transistor features. In addition, nanoparticles (ultra-small particles with a diameter of a few nanometres) have unique functions and can be used to deliver drugs and other therapeutic molecules because of their small size which enables them to permeate towards therapeutic targets in the body and to penetrate cells to deliver therapeutic compounds. In our ambitious research project, we will synthesize innovative classes of nanostructured lipid conjugates (NLCs) containing bio-derived and biocompatible lipids, peptides and sugars linked together into multi-functional molecules. Combining these natural molecules by linking different components will lead to new structures and functions. We will investigate the formation of nanoscale ordered structures in these materials in the melt as a function of temperature using x-rays and advanced microscopes. Many of these NLCs have not been studied before and will have unique and unexpected properties and functions. A particular focus will be on those NLCs which produce the smallest feature sizes which will be used to create new nanoporous membranes for filtration applications and nanopatterned surfaces with novel properties as coatings and for catalysis. Films will be made from unusual types of lipids that form the cell membrane of extremophile organisms which can withstand extreme environmental conditions of pH and temperature (being found for example near deep-sea vents). We will use micelles and vesicles which are ultra-small structures formed by surfactants and lipids in water and which are already on the market, being used in cosmetics and medicine. The detergency properties, biodegradability and eco-friendly nature of the biosurfactant NLCs will be analysed. Finally, these structures will be used to encapsulate and deliver model compounds and anticancer drugs, exploiting the peptide and sugar coating on the nanoparticles to achieve selective targeting to cancer cells, using tumour-specific chemical triggers. This is a cutting edge project that will deliver transformative discoveries using materials that will be designed taking inspiration from nature and using nature's palette of biomolecular functions, which have been evolved for optimal performance under specific conditions. This project addresses important unmet needs for new types of eco-friendly biosurfactants and advanced functional nanomaterials based on rational control of biomolecular self-assembly. An Established Career Fellowship will provide the flexibility to develop these exciting NLC systems based on a clear vision to exploit biomolecular self-assembly to create innovative materials that address major environmental and healthcare challenges.

纳米材料是具有几纳米大小的特征的材料，比人类头发的宽度小数千倍。它们作为创新的先进材料在过滤中的应用具有巨大的兴趣，因为它们可以捕获非常小的颗粒，如细菌和病毒。此外，对于非常小的颗粒，催化剂的活性大大增加，例如在发动机催化转化器中。用于最新一代笔记本电脑、电脑和智能手机的硅芯片依赖于增加芯片上晶体管的数量，这是通过减小晶体管特征的尺寸来实现的。此外，纳米颗粒（直径为几纳米的超小颗粒）具有独特的功能，并且可以用于递送药物和其他治疗分子，因为它们的小尺寸使它们能够渗透到体内的治疗靶点并穿透细胞以递送治疗化合物。在我们雄心勃勃的研究项目中，我们将合成创新类的纳米结构脂质缀合物（NLC），其中含有生物衍生的和生物相容的脂质，肽和糖连接在一起成为多功能分子。通过连接不同的成分来组合这些天然分子将导致新的结构和功能。我们将研究这些材料在熔体中的纳米级有序结构的形成，作为温度的函数，使用X射线和先进的显微镜。这些NLC中的许多以前没有被研究过，并且将具有独特和意想不到的性质和功能。一个特别的重点将是那些产生最小特征尺寸的NLC，这些特征尺寸将用于创建用于过滤应用的新纳米多孔膜和具有新特性的纳米图案化表面，如涂层和催化。薄膜将由形成极端微生物细胞膜的不寻常类型的脂质制成，这种微生物可以承受pH和温度等极端环境条件（例如在深海喷口附近发现）。我们将使用胶束和囊泡，它们是由表面活性剂和脂质在水中形成的超小结构，已经上市，用于化妆品和药物。将分析生物表面活性剂NLC的去污性能、生物降解性和生态友好性。最后，这些结构将用于封装和递送模型化合物和抗癌药物，利用纳米颗粒上的肽和糖涂层，使用肿瘤特异性化学触发剂实现对癌细胞的选择性靶向。这是一个前沿项目，将使用从自然界中汲取灵感并使用自然界生物分子功能调色板设计的材料提供变革性发现，这些功能已在特定条件下进化为最佳性能。该项目解决了基于合理控制生物分子自组装的新型生态友好型生物表面活性剂和先进功能纳米材料的重要未满足的需求。一个既定的职业奖学金将提供灵活性，开发这些令人兴奋的NLC系统的基础上一个明确的愿景，利用生物分子自组装，创造创新材料，解决主要的环境和医疗保健挑战。