SBIR Phase II: Coherent Optical Nonlinear Microscopy

这个小型企业创新研究（SBIR）第二阶段项目将展示一种新型的高分辨率激光显微镜，其分辨率可以优于所用激光波长的五分之一。 激光显微镜可以从近红外到近紫外操作。 在400 nm处工作，该显微镜将提供80 nm分辨率或1/5，工作距离为几毫米，焦深为许多波长。该项目包括设计一个适合商业部署的原型。 该计划的双重目标是在实验室的光学台上展示该技术，以及设计所需的广泛商业化的核心光学器件。 研究将包括：（1）在不同波长下对仪器进行完整的表征，（2）在商业上重要的衬底（如硅和生物样品）上进行实验，以及（3）开发紧凑的原型“物镜”以提高性能。 第二阶段的实验将使用半导体工业的生物标本和面具来建立这项技术。 科学研究实验室将在第二阶段继续与业界合作，以利用NSF的投资，并迅速将拟议的技术进入第三阶段。

This Small Business Innovation Research (SBIR) Phase II project will demonstrate a novel, high resolution laser microscope whose resolution can be better than a fifth of the wavelength of the laser utilized. The laser microscope can be operated from the near infrared to near ultraviolet. Operating at 400nm, this microscope will provide 80nm resolution or l/5 with working distance of several millimeters and depth of focus of many wavelengths. The project includes designing a prototype suitable for commercial deployment. The dual objectives of the program are to demonstrate the technology on an optical table in the laboratory as well as to design the core optics for required wide spread commercialization. The research will include: (1) complete characterization of the instrument at different wavelengths, (2) experiments on commercially important substrates like silicon and biological specimen, and (3) development of a compact prototype "objective" to improve performance. Biological specimens as well as masks from the semiconductor industry will be used in the experiments in Phase II to establish the technique. Science Research Laboratory will continue to work with the industry during Phase II so as to leverage NSF's investment and rapidly move the proposed technology into Phase III.