Development of a diagnostic microarray to detect aneuploidy in single cells

开发用于检测单细胞非整倍性的诊断微阵列

• 批准号: LP100200800
• 负责人: Prof Frank Gruetzner
• 金额: $ 9.04万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-18 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP100200800
• 关键词: Development; diagnostic; microarray; detect; aneuploidy

Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health service delivered to the Australian public. This project aims to develop better tests for application in prenatal diagnostics including non-invasive testing of fetal cells from maternal circulation or cervical samples at 6-13 weeks gestation, IVF and cancer diagnostics.

染色体异常占所有出生缺陷婴儿的10%左右。染色体异常的风险随着母亲年龄的增长和有生育问题的患者而增加。据估计，50%的胚胎是非整倍体。 染色体畸变也发生在绝大多数人类肿瘤中。准确和快速检测染色体缺陷是向澳大利亚公众提供的一项重要保健服务。该项目旨在开发更好的检测方法，用于产前诊断，包括对妊娠6-13周的母体循环或宫颈样本中的胎儿细胞进行非侵入性检测、体外受精和癌症诊断。