Soluble Complexes of DNA and Cationic Polymers for Gene Delivery

用于基因传递的 DNA 和阳离子聚合物的可溶性复合物

• 批准号: 9907281
• 负责人: Alexander Kabanov
• 金额: $ 34.95万
• 依托单位: University of Nebraska Medical Center
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-15 至 2004-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9907281&HistoricalAwards=false
• 关键词: Soluble; Complexes; DNA; Cationic; Polymers

The objective of this project is to develop soluble complexes of DNA with cationic polymers for use in gene delivery to cells. The objectives described in the proposal are threefold: (1) to examine the efficacy of gene transfer of DNA/polycation complexes of various molecular architectures; (2) to study cellular mechanisms for delivery of the complexes into the cell; and (3) to evaluate the efficacy of gene transfer of DNA/polycation complexes containing attached proteins and peptides.

本项目的目的是开发可溶性DNA与阳离子聚合物的复合物，用于向细胞递送基因。 该提案中描述的目标有三个方面：（1）检查各种分子结构的DNA/聚阳离子复合物的基因转移功效;（2）研究将复合物递送到细胞中的细胞机制;（3）评估含有附着蛋白质和肽的DNA/聚阳离子复合物的基因转移功效。