Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing

了解生殖和性冲突如何导致性别依赖的长寿和衰老

• 批准号: DP1092465
• 负责人: Prof Robert Brooks
• 金额: $ 66.52万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-04-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092465
• 关键词: Understanding; how; reproduction; sexual; conflict

The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evolutionary and mechanistic spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels.

长寿和衰老的生物学研究有两个重要方面：了解进化如何塑造寿命和衰老，以及分子，基因，激素，组织和细胞在衰老过程中如何相互作用的机制研究。衰老的进化研究被认为是进化医学新兴领域的成功案例之一，但我们迫切需要更大程度地整合进化和机械领域。该项目探讨了为什么男性和女性有不同的寿命和不同的年龄，以一种连接进化和机械研究的方式，并将建立澳大利亚在这两个层面上研究老龄化的研究能力。