Linking the evolutionary and bioenergetic causes of sex differences in lifespan and ageing.

将寿命和衰老中性别差异的进化和生物能量原因联系起来。

• 批准号: DP0984240
• 负责人: Prof Robert Brooks
• 金额: $ 38.8万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-03-01 至 2012-03-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984240
• 关键词: Linking; evolutionary; bioenergetic; causes; sex

The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how genes, hormones, tissues and cells interact during ageing. Interventions to prolong longevity and improve quality of life depend on a vigorous and innovative research effort in both spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Because of the human interest in diet, sex, reproduction and ageing, we expect this research will be a showcase for public interest in science.

长寿和衰老的生物学研究有两个重要的前沿：理解进化如何塑造寿命和衰老，以及基因、激素、组织和细胞在衰老过程中如何相互作用的机制研究。延长寿命和提高生活质量的干预措施取决于在这两个领域进行积极和创新的研究工作。该项目以一种连接进化和机械研究的方式解决了男性和女性寿命和年龄不同的原因，并将建立澳大利亚在两个层面上研究衰老的研究能力。由于人类对饮食、性、生殖和衰老的兴趣，我们期望这项研究将成为公众对科学兴趣的展示。