Lipid and Carbohydrate Based Systems to Target and Deliver Peptide Drug Candidates to Specific Cells

基于脂质和碳水化合物的系统将候选肽药物靶向并递送至特定细胞

• 批准号: DP1092829
• 负责人: Prof Istvan Toth
• 金额: $ 52.26万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-07-01 至 2013-12-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092829
• 关键词: Lipid; Carbohydrate; Based; Systems; Target

The demand for novel effective, orally available medicines to treat a wide range of diseases (cancer, pain - ageing Australian population) is increasing exponentially. Conjugation of peptide drug or vaccine candidates with lipids and/or sugars represents an important, novel strategy in the drug delivery and targeting field. Increasing the lipophilicity improves absorption through intestinal mucosal membranes. The carbohydrates increase the compound's aqueous solubility and can utilize active transport systems and can target the site required for its biological function. There is no limit to the areas of medicine and public health that would benefit from this revolutionary new technology.

对治疗各种疾病（癌症、疼痛-澳大利亚人口老龄化）的新型有效口服药物的需求呈指数级增长。肽药物或疫苗候选物与脂质和/或糖的缀合代表了药物递送和靶向领域中的重要的新颖策略。增加亲脂性改善通过肠粘膜的吸收。碳水化合物增加了化合物的水溶性，可以利用主动转运系统，并可以靶向其生物功能所需的位点。从这项革命性的新技术中受益的医学和公共卫生领域没有限制。