Lipid and Carbohydrate Based Systems to Target and Deliver Peptide Drug Candidates to Specific Cells
Lipid and Carbohydrate Based Systems to Target and Deliver Peptide Drug Candidates to Specific Cells
批准号:
DP1092829
负责人:
Prof Istvan Toth
金额:
$52.26万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-07-01 至 2013-12-30
中文摘要
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英文摘要
The demand for novel effective, orally available medicines to treat a wide range of diseases (cancer, pain - ageing Australian population) is increasing exponentially. Conjugation of peptide drug or vaccine candidates with lipids and/or sugars represents an important, novel strategy in the drug delivery and targeting field. Increasing the lipophilicity improves absorption through intestinal mucosal membranes. The carbohydrates increase the compound's aqueous solubility and can utilize active transport systems and can target the site required for its biological function. There is no limit to the areas of medicine and public health that would benefit from this revolutionary new technology.
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海外基金