Understanding the myometrial transition at term and preterm labour to guide tocolysis

了解足月和早产时子宫肌层的转变以指导安胎

• 批准号: nhmrc : 1126795
• 负责人: Prof Istvan Toth
• 金额: $ 55.22万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-myometrial-transition-guide-tocolysis/947860
• 关键词: Understanding; myometrial; transition; term; preterm

This grant seeks to understand how the muscle cells of the uterus transform at the time of labour. We propose that this transformation is organised by enzymes that modify the histones around key genes. We will test if a similar pathway operates in cases of preterm labour. The results will guide the development of new ways of treating premature labour that will use targeted nanoparticles to deliver siRNA directly to the muscle cells of the uterus.

这项资助旨在了解子宫的肌肉细胞在分娩时如何转变。我们认为这种转化是由修饰关键基因周围组蛋白的酶组织的。我们将测试在早产的情况下是否有类似的途径。研究结果将指导治疗早产的新方法的开发，该方法将使用靶向纳米颗粒将siRNA直接递送到子宫的肌肉细胞。