SBIR Phase I: Advanced Positron Annihilation Mass Spectrometer

这个小企业创新研究第一阶段项目将建立一个大大改进的质谱仪的基础上湮灭的正电子的可行性。 该项目的基础是利用缓冲气体在Penning阱中积累放射源正电子技术的最新发展。先进的正电子质谱仪将使用正电子来精确控制复杂分子的电离和碎裂。第一阶段的技术目标是：（1）组装一个实验，研究生物分子的正电子电离质谱;（2）进行实验，比较这些分子的正电子电离性能与目前使用的离子源质谱;和（3）进行概念设计的实验室原型系统的第二阶段。第一阶段的可行性实验将在圣地亚哥的加州大学的正电子阱上进行。如果成功，该项目将为第二阶段质量谱仪的实验室原型演示提供基础。第一和第二阶段将为第三阶段的新技术商业化奠定基础。该项目涉及1999年具有国家重要性的关键技术-生物技术。

This Small Business Innovation Research Phase I project will establish the feasibility of developing a greatly improved mass spectrometer based on the annihilation of positrons. The project is based on the latest developments in techniques to accumulate positrons from a radioactive source in Penning traps using a buffer gas. The Advanced Positron Mass Spectrometer will use positrons to control precisely the ionization and fragmentation of complex molecules. The technical objectives of Phase I are to: (1) assemble an experimentto investigate positron ionization mass spectrometry of biomolecules; (2) perform experiments to compare the performance of positron ionization of these molecules with currently used ion sources for mass spectrometry; and (3) carry out the conceptual design of a laboratory prototype system for Phase II. The Phase I feasibility experiments will be performed on the positron trap at the University of California, San Diego. If successful, this project will provide the basis for demonstration of a laboratory prototype of themass spectrometer in Phase II. Phase I and II will provide the foundation for commercializing the new technology in Phase III. This project addresses a 1999 critical technology of national importance, biotechnology.