Soft materials containing hierarchy via 3D sacrificial micro-moulding

通过 3D 牺牲微成型制造出具有层次结构的软质材料

• 批准号: FT150100408
• 负责人: Prof Tim Dargaville
• 金额: $ 55.99万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-06-01 至 2020-11-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT150100408
• 关键词: Soft; materials; containing; hierarchy; via

The project seeks to develop sophisticated new polymeric materials and devices not possible using current manufacturing techniques. Biomaterials based on hydrogels are ideal substrates for synthetic extra-cellular matrices due to their high water content. However, one of the challenges hindering the use of hydrogels is reproducing the transport properties found in natural tissue with hierarchical features such as vascularisation. To address this, the project plans to develop a 3D moulding process for generating soft materials containing precise channels decorated with defined molecules. Intended outcomes include a fundamental understanding of the 3D moulding process, and new polymers and advanced tools for bioengineers for future applications such as tissue transplants, cell guides for treating spinal cord injuries, soft robotics and microfluidic devices to study cancer metastasis.

该项目寻求开发复杂的新聚合物材料和设备，使用现有的制造技术是不可能的。基于水凝胶的生物材料因其高含水率而成为合成细胞外基质的理想基质。然而，阻碍水凝胶使用的挑战之一是复制在自然组织中发现的具有分层特征的运输特性，如血管形成。为了解决这个问题，该项目计划开发一种3D模塑工艺，以产生含有用限定分子装饰的精确通道的软材料。预期成果包括对3D成型过程的基本了解，以及生物工程师未来应用的新聚合物和先进工具，如组织移植、治疗脊髓损伤的细胞导向器、软机器人和研究癌症转移的微流体设备。