RUI: A 300 MHz Nuclear Magnetic Resonance Spectrometer for Multidisciplinary Structural Studies

该合同支持田纳西理工大学化学系用于多学科结构研究的300 MHz多核核磁共振谱仪的收购。将从新仪器中受益的大部分教员来自多学科，即生物有机、生物化学、生物无机、医学和环境。主要研究人员从事多学科研究，涉及生物和基本重要分子的合成。需要这种仪器的研究领域包括：1)含氟分子的合成，2)吲哚类似物和非天然氨基酸的合成，3)用于环境修复的螯合剂的合成，4)新的含金属氨基酸的合成，5)生物结合核的核磁共振研究，6)锶和铼配合物的合成。这些领域的研究可能导致可在各种重要领域利用的技术，例如制药业(药物设计)和环境清理行动。众所周知，21世纪的健康和环境问题都摆在面前，需要加以解决。对化学结构的原子水平的理解对于挑战这些障碍是必要的。用来阐明这些研究领域中所研究的化合物结构的最重要的工具是核磁共振波谱。这些研究需要对各种原子核进行分析，以便进行适当的表征。就我们的目的而言，这些原子核包括氢、碳、磷、氟、硼、硅、硒和碲。所要求的仪器能够调谐到所有这些原子核。田纳西理工大学是一所以本科生为主的大学，在本科生研究方面有严格的课程。化学系每年派10-15名学生参加国家和地区会议，在那里他们展示他们的研究成果。获得这种仪器对学院的研究计划和系继续发展这个本科生多学科研究计划都是至关重要的。田纳西理工大学位于纳什维尔和诺克斯维尔之间，为田纳西州中东部提供服务。大多数系毕业生计划在医学或生物技术专业就业，并最终进入研究生院、专业学校、工业或医学院。大多数研究是由教师、研究生和本科生进行的。系里有16名全职教职员工。

9970016Abstract This award supports an acquisition of a 300 MHz multi-nuclea NMR spectrometer for multidisciplinary structural studies in the Chemistry department at Tennessee Tech University. The majority of the faculty which will benefit from the new instrumentation are of multi-disciplinary origin,i.e., bioorganic, biochemical, bioinorganic, medicinal, and environmental. The principal investigators are engaged in multi-disciplinary research that involves the synthesis of molecules of biological and fundamental importance. Research areas which require this instrumentation include: 1) synthesis offluorine-containing molecules, 2) synthesis of indole analogs and unnatural amino acids, 3) synthesis of chelating agents for environmental remediation, 4)synthesis of new metalloid-containing amino acids 5)study of bio-incorporated nuclei via NMR spectroscopy, and 6)synthesis of technetium and rhenium complexes. Research in these areas may lead to techniques that can be exploited in a variety of important areas, such as the pharmaceutical industry (drug design) and environmental clean-up operations. It is a known fact that both health and environmental problems lie ahead in the 21st century and will need to beaddressed. The atomic level understanding of chemical structure is necessary to challenge these hurdles. The most important tool for elucidating the structure of compounds studied in these research areas is Nuclear Magnetic Resonance (NMR) spectroscopy. These studies require analysis of a variety of atomic nuclei for proper characterization. For our purposes, these nuclei include hydrogen, carbon, phosphorus, fluorine, boron, silicon, selenium, and tellurium. The requested instrumentation is capable of being tuned to all of these nuclei. Tennessee Tech is a predominantly undergraduate institution that has a rigorous program in undergraduate research. The chemistry department sends 10-15 students per year to national and regional meetings where they present the results of their research findings. The acquisition of this instrumentation isvital to both the faculty research programs and to the department's continued development of this undergraduate multidisciplinary research program. Tennessee Tech is located midway between Nashville and Knoxville, serving the east-central portion of Tennessee. Most of the department graduates plan careers in the medical or biotechnology profession and ultimately attend graduate schools, professional schools, industry, or medical schools. Most research is carried out by faculty, graduate students, and undergraduates.The department has sixteen full-time faculty members.