RUI: A 300 MHz Nuclear Magnetic Resonance Spectrometer for Multidisciplinary Structural Studies

9970016摘要该奖项支持田纳西理工大学化学系购买一台300 MHz多核NMR光谱仪，用于多学科结构研究。 受益于新仪器的大多数教师都是多学科出身，即，生物有机的、生物化学的、生物无机的、医学的和环境的。主要研究人员从事多学科研究，涉及生物和基本重要性分子的合成。 需要这种仪器的研究领域包括：1）含氟分子的合成，2）吲哚类似物和非天然氨基酸的合成，3）用于环境修复的螯合剂的合成，4）新的含类金属氨基酸的合成，5）通过NMR光谱研究生物掺入核，以及6）锝和锝络合物的合成。 在这些领域的研究可能会产生可用于制药业（药物设计）和环境清理作业等各种重要领域的技术。 众所周知，健康和环境问题都摆在21世纪世纪的前面，需要加以解决。 原子水平的化学结构理解是挑战这些障碍所必需的。在这些研究领域中，用于阐明化合物结构的最重要工具是核磁共振（NMR）光谱。这些研究需要对各种原子核进行分析，以进行适当的表征。 就我们的目的而言，这些原子核包括氢、碳、磷、氟、硼、硅、硒和碲。 所要求的仪器能够调谐到所有这些原子核。田纳西理工学院是一所以本科为主的机构，在本科研究方面有严格的计划。化学系每年派遣10-15名学生参加国家和地区会议，在那里他们展示他们的研究成果。这种仪器的收购是至关重要的教师的研究计划和部门的持续发展的本科多学科研究计划。田纳西理工学院位于纳什维尔和诺克斯维尔之间，服务于田纳西州的中东部。大多数部门的毕业生计划在医学或生物技术专业的职业生涯，并最终参加研究生院，专业学校，工业或医学院。大部分的研究工作是由教师、研究生和本科生进行的。该系有16名全职教师。

9970016Abstract This award supports an acquisition of a 300 MHz multi-nuclea NMR spectrometer for multidisciplinary structural studies in the Chemistry department at Tennessee Tech University. The majority of the faculty which will benefit from the new instrumentation are of multi-disciplinary origin,i.e., bioorganic, biochemical, bioinorganic, medicinal, and environmental. The principal investigators are engaged in multi-disciplinary research that involves the synthesis of molecules of biological and fundamental importance. Research areas which require this instrumentation include: 1) synthesis offluorine-containing molecules, 2) synthesis of indole analogs and unnatural amino acids, 3) synthesis of chelating agents for environmental remediation, 4)synthesis of new metalloid-containing amino acids 5)study of bio-incorporated nuclei via NMR spectroscopy, and 6)synthesis of technetium and rhenium complexes. Research in these areas may lead to techniques that can be exploited in a variety of important areas, such as the pharmaceutical industry (drug design) and environmental clean-up operations. It is a known fact that both health and environmental problems lie ahead in the 21st century and will need to beaddressed. The atomic level understanding of chemical structure is necessary to challenge these hurdles. The most important tool for elucidating the structure of compounds studied in these research areas is Nuclear Magnetic Resonance (NMR) spectroscopy. These studies require analysis of a variety of atomic nuclei for proper characterization. For our purposes, these nuclei include hydrogen, carbon, phosphorus, fluorine, boron, silicon, selenium, and tellurium. The requested instrumentation is capable of being tuned to all of these nuclei. Tennessee Tech is a predominantly undergraduate institution that has a rigorous program in undergraduate research. The chemistry department sends 10-15 students per year to national and regional meetings where they present the results of their research findings. The acquisition of this instrumentation isvital to both the faculty research programs and to the department's continued development of this undergraduate multidisciplinary research program. Tennessee Tech is located midway between Nashville and Knoxville, serving the east-central portion of Tennessee. Most of the department graduates plan careers in the medical or biotechnology profession and ultimately attend graduate schools, professional schools, industry, or medical schools. Most research is carried out by faculty, graduate students, and undergraduates.The department has sixteen full-time faculty members.