300 MHz NMR spectrometer console

300 MHz 核磁共振波谱仪控制台

• 批准号: 443450867
• 金额: --
• 依托单位: Philipps-Universität Marburg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/443450867?language=en
• 关键词: 300; MHz; NMR; spectrometer; console

NMR spectroscopy is the most important method for the analysis of molecular structures that are synthesized in the working groups of organic and inorganic chemistry in our department. The analytical questions range from the spin systems of complex CH frameworks over NMR-active hetero-nuclei to the characterization of intermolecular interactions and relaxation properties. The synthesis of polypeptides, natural products and catalysts in organic chemistry requires the structure elucidation of numerous intermediates, for which a reliable NMR analysis is a requirement. Since there are no reference spectra for these new molecular structures, the structural evidence must generally be carried out using two-dimensional NMR methods. Just as many structural questions come from inorganic chemistry, with the focus more on the determination of heteroatoms such as fluorine and phosphorus, but also elements with nuclear spin > ½. The highly experimental education brings students in contact with the NMR spectrometers at an early stage. The pyramidal structure of our spectrometers has proven itself for the complexity of scientific questions: one 600, two 500 and four 300/250. With the failure of our oldest 300 MHz spectrometer console, a quarter of the measurement time previously available for the low-field spectrometers has been lost. This limitation has to be compensated for by purchasing a new console. The developments in computer technology in recent years have made modern NMR consoles versatile instruments that offer not only increased sensitivity, but also new NMR techniques, which can be used to clarify new scientific questions. The applicants have high expectations for the technology of "multi-receiver acquisition". Heteronuclear correlations can thus be measured much more efficiently, since correlations that are independent of one another, e.g. H,H- or C,F- are detected simultaneously and two NMR measurements are carried out simultaneously in one measurement time window. The associated considerable reduction in the total measuring time not only ensures more efficient use of the spectrometer, it also enables, for example, thecomplete NMR analysis of unstable reaction intermediates that would decompose with longer measuring times. All working groups represented in this application can benefit from these new NMR techniques.

NMR光谱是分析分子结构的最重要的方法，这些分子结构是在我们部门的有机和无机化学工作组中合成的。分析问题的范围从复杂的CH框架NMR活性杂核的自旋系统的分子间相互作用和弛豫特性的表征。在有机化学中，多肽、天然产物和催化剂的合成需要对许多中间体进行结构解析，而可靠的NMR分析是其中的一个必要条件。由于这些新的分子结构没有参考光谱，因此通常必须使用二维NMR方法进行结构证据。正如许多结构问题来自无机化学，重点更多地放在确定杂原子，如氟和磷，以及核自旋> 1/2的元素。高度实验性的教育使学生在早期接触NMR光谱仪。我们光谱仪的金字塔结构已经证明了其对于科学问题的复杂性：一个600，两个500和四个300/250。随着我们最老的300 MHz光谱仪控制台的故障，以前用于低场光谱仪的测量时间已经损失了四分之一。这种限制必须通过购买新的控制台来补偿。近年来计算机技术的发展使现代核磁共振控制台成为多功能仪器，不仅提高了灵敏度，还提供了新的核磁共振技术，可用于澄清新的科学问题。申请人对“多接收机捕获”技术有很高的期望。因此，可以更有效地测量异频相关性，因为同时检测彼此独立的相关性，例如H，H-或C，F-，并且在一个测量时间窗口中同时进行两个NMR测量。总测量时间的显著减少不仅确保了光谱仪的更有效使用，还实现了对不稳定反应中间体的完整NMR分析，这些中间体在较长的测量时间内会分解。本申请中所代表的所有工作组都可以从这些新的NMR技术中受益。