300 MHz NMR spectrometer console

300 MHz 核磁共振波谱仪控制台

• 批准号: 443450867
• 金额: --
• 依托单位: Philipps-Universität Marburg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/443450867?language=en
• 关键词: 300; MHz; NMR; spectrometer; console

NMR spectroscopy is the most important method for the analysis of molecular structures that are synthesized in the working groups of organic and inorganic chemistry in our department. The analytical questions range from the spin systems of complex CH frameworks over NMR-active hetero-nuclei to the characterization of intermolecular interactions and relaxation properties. The synthesis of polypeptides, natural products and catalysts in organic chemistry requires the structure elucidation of numerous intermediates, for which a reliable NMR analysis is a requirement. Since there are no reference spectra for these new molecular structures, the structural evidence must generally be carried out using two-dimensional NMR methods. Just as many structural questions come from inorganic chemistry, with the focus more on the determination of heteroatoms such as fluorine and phosphorus, but also elements with nuclear spin > ½. The highly experimental education brings students in contact with the NMR spectrometers at an early stage. The pyramidal structure of our spectrometers has proven itself for the complexity of scientific questions: one 600, two 500 and four 300/250. With the failure of our oldest 300 MHz spectrometer console, a quarter of the measurement time previously available for the low-field spectrometers has been lost. This limitation has to be compensated for by purchasing a new console. The developments in computer technology in recent years have made modern NMR consoles versatile instruments that offer not only increased sensitivity, but also new NMR techniques, which can be used to clarify new scientific questions. The applicants have high expectations for the technology of "multi-receiver acquisition". Heteronuclear correlations can thus be measured much more efficiently, since correlations that are independent of one another, e.g. H,H- or C,F- are detected simultaneously and two NMR measurements are carried out simultaneously in one measurement time window. The associated considerable reduction in the total measuring time not only ensures more efficient use of the spectrometer, it also enables, for example, thecomplete NMR analysis of unstable reaction intermediates that would decompose with longer measuring times. All working groups represented in this application can benefit from these new NMR techniques.

核磁共振波谱是分析我系有机化学和无机化学工作组合成的分子结构的最重要的方法。分析问题的范围从核磁共振活性杂核上复杂的CH骨架的自旋系统到分子间相互作用和驰豫性质的表征。在有机化学中，多肽、天然产物和催化剂的合成需要大量中间体的结构鉴定，而对中间体进行可靠的核磁共振分析是必不可少的。由于这些新的分子结构没有参考光谱，结构证据通常必须使用二维核磁共振方法进行。正如许多结构问题来自无机化学一样，重点更多地放在氟和磷等杂原子的测定上，但也包括具有核自旋的元素。高度的实验教学让学生在早期阶段就接触到了核磁共振波谱仪。我们的光谱仪的金字塔结构已经证明了它自己适用于复杂的科学问题：一个600，两个500和四个300/250。随着我们最老的300 MHz光谱仪控制台的故障，以前用于低场光谱仪的测量时间已经损失了四分之一。这一限制必须通过购买新的游戏机来弥补。近年来计算机技术的发展使现代核磁共振控制台变得多才多艺，不仅提供了更高的灵敏度，而且还提供了新的核磁共振技术，可以用来澄清新的科学问题。申请者对“多机捕获”技术寄予厚望。因此，可以更有效地测量异核关联，因为同时检测彼此独立的关联，例如H、H-或C、F-，并且在一个测量时间窗口中同时进行两个核磁共振测量。总测量时间的显著减少不仅确保了光谱仪的更高效使用，还使不稳定的反应中间产物能够进行完整的核磁共振分析，这些中间产物会随着测量时间的延长而分解。本申请中所代表的所有工作组都可以从这些新的核磁共振技术中受益。