300 MHz NMR spectrometer console

300 MHz 核磁共振波谱仪控制台

• 批准号: 443450867
• 金额: --
• 依托单位: Philipps-Universität Marburg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/443450867?language=en
• 关键词: 300; MHz; NMR; spectrometer; console

NMR spectroscopy is the most important method for the analysis of molecular structures that are synthesized in the working groups of organic and inorganic chemistry in our department. The analytical questions range from the spin systems of complex CH frameworks over NMR-active hetero-nuclei to the characterization of intermolecular interactions and relaxation properties. The synthesis of polypeptides, natural products and catalysts in organic chemistry requires the structure elucidation of numerous intermediates, for which a reliable NMR analysis is a requirement. Since there are no reference spectra for these new molecular structures, the structural evidence must generally be carried out using two-dimensional NMR methods. Just as many structural questions come from inorganic chemistry, with the focus more on the determination of heteroatoms such as fluorine and phosphorus, but also elements with nuclear spin > ½. The highly experimental education brings students in contact with the NMR spectrometers at an early stage. The pyramidal structure of our spectrometers has proven itself for the complexity of scientific questions: one 600, two 500 and four 300/250. With the failure of our oldest 300 MHz spectrometer console, a quarter of the measurement time previously available for the low-field spectrometers has been lost. This limitation has to be compensated for by purchasing a new console. The developments in computer technology in recent years have made modern NMR consoles versatile instruments that offer not only increased sensitivity, but also new NMR techniques, which can be used to clarify new scientific questions. The applicants have high expectations for the technology of "multi-receiver acquisition". Heteronuclear correlations can thus be measured much more efficiently, since correlations that are independent of one another, e.g. H,H- or C,F- are detected simultaneously and two NMR measurements are carried out simultaneously in one measurement time window. The associated considerable reduction in the total measuring time not only ensures more efficient use of the spectrometer, it also enables, for example, thecomplete NMR analysis of unstable reaction intermediates that would decompose with longer measuring times. All working groups represented in this application can benefit from these new NMR techniques.

核磁共振波谱是我系有机和无机化学工作组合成的最重要的分子结构分析方法。分析问题范围从 NMR 活性异核上复杂 CH 框架的自旋系统到分子间相互作用和弛豫特性的表征。有机化学中多肽、天然产物和催化剂的合成需要对众多中间体进行结构解析，为此需要可靠的核磁共振分析。由于这些新分子结构没有参考光谱，结构证据通常必须使用二维核磁共振方法进行。正如许多结构问题来自无机化学一样，更多地关注氟和磷等杂原子的测定，但也关注核自旋 > 1/2 的元素。高度实验性的教育使学生很早就接触了核磁共振波谱仪。我们光谱仪的金字塔结构已证明能够应对复杂的科学问题：一个 600、两个 500 和四个 300/250。由于我们最旧的 300 MHz 光谱仪控制台出现故障，低场光谱仪之前可用的测量时间已损失了四分之一。这种限制必须通过购买新的控制台来弥补。近年来计算机技术的发展使现代核磁共振控制台成为多功能仪器，不仅提供更高的灵敏度，而且提供新的核磁共振技术，可用于阐明新的科学问题。申请人对“多接收器采集”技术抱有很高的期望。因此，可以更有效地测量异核相关性，因为彼此独立的相关性，例如同时检测 H,H- 或 C,F-，并在一个测量时间窗口内同时进行两次 NMR 测量。总测量时间的显着减少不仅确保了光谱仪的更有效使用，而且还能够对不稳定的反应中间体进行完整的 NMR 分析，这些中间体会在更长的测量时间内分解。本申请中代表的所有工作组都可以从这些新的 NMR 技术中受益。