Introducing NMR into the Techniques and Projects Program in Organic Chemistry Laboratory: A Research - Based Project Experience

作为正在进行的课程改革的一部分，阿尔比恩学院化学系正在将现有的核磁共振波谱仪升级为多核傅里叶变换(FT)核磁共振波谱仪。此次升级(Anasazi，Inc.)是为了响应教育部在有机化学实验室采用的新方法，以及技术和项目组成部分计划。这种方法植根于越来越多的研究型实验室的运动，例如由阿门塔和莫斯博、利赫特和瑟洛(国家科学基金会-DUE 9456035)以及哈拉斯(NSF-DUE 9455681)开发的实验室。对这种理想的积极追求需要使用现代分析仪器。我们正在以这些创新项目为基础，使它们适应我们自己对化学教育未来的机构和部门愿景。这一愿景包括尽快和尽可能频繁地让学生参与真实的研究体验。通过使用现代FT-核磁共振波谱，我们的学生可以体验到更真实的研究环境。技术和项目组件课程将学生置于基于项目的研究体验的中心，并为学生提供调查研究问题所需的工具和技能。学生体验多种研究环境，包括：图书馆和在线文献和结构搜索，在有机实验室进行新颖的实验，以及在仪器实验室仔细分析实验样品。实验经验分为两部分：技术(化学211L和化学212L的前5周)和项目(化学212L的最后9周)。每个组成部分都为学生提供了充分的机会与研究经验建立积极的联系。技术部分侧重于获得适当的实验室技能。在这一组成部分中内置了一些以研究为基础的实验室。项目部分是为期九周的体验，学生在其中进行自己的研究项目。这包括在文献中搜索有关该项目的信息，找到或设计合适的实验，并分析这些实验的结果。已经建议了一些项目供学生调查，并鼓励学生创建自己的项目，但需得到教师的批准。对反应产物的光谱分析是这两种成分的必要组成部分。在我们这个新的实验室计划的第一年之后，对核磁共振分析的需求已经变得明显。升级后的仪器是这次课程修订成功的关键，因为它允许学生自己获得更完整的光谱数据集，用于产品和中间分析。反过来，这又为学生提供了对他们在现代研究环境中进行操作的能力至关重要的经验。

As part of its ongoing curriculum reform, the Chemistry Department at Albion College is upgrading an existing NMR spectrometer to a multinuclear Fourier Transform (FT) NMR spectrometer. This upgrade (Anasazi, Inc.) is in response to the new approach the department has taken in the organic chemistry laboratory with the Techniques and Projects Component Program. This approach is rooted in the growing movement towards research-based laboratories, such as those developed by Amenta and Mosbo, Licht and Thurlow (NSF-DUE 9456035), and Kharas (NSF-DUE 9455681). An aggressive pursuit of such ideals requires the use of modern analytical instrumentation. We are building on these innovative programs as we adapt them to our own institutional and departmental vision for the future of chemical education. This vision includes involving students in authentic research experiences as soon and as often as possible. Access to modern FT-NMR spectroscopy allows our students to experience a more realistic research environment.The Techniques and Projects Component Program places the student in the center of a project-based research experience and provides the student with the necessary tools and skills to investigate a research problem. The student experiences multiple research environments including: library and on-line literature and structure searches, performing novel experiments in the organic laboratory, and careful analysis of experimental samples in the instrument laboratory. The laboratory experience is divided into two components; Techniques (Chem 211L and the first 5 weeks of Chem 212L) and Projects (the last 9 weeks of Chem 212L). Each component provides ample opportunity for students to make positive connections with the research experience. The Techniques component focuses on the acquisition of proper laboratory skills. Built into this component are a number of research-based laboratories. The Projects component is a nine-week experience in which the students carry out their own research projects. This includes searching the literature for information about the project, finding or designing appropriate experiments, and analyzing the outcomes of these experiments. A number of projects have been suggested for students to investigate, and the student are encouraged to create their own, subject to instructor approval. Spectroscopic analysis of reaction products is a necessary part of both components. Following our first year of this new laboratory program, the need for NMR analysis has become evident. The upgraded instrument is critical to the success of this curriculum revision in that it allows students to obtain for themselves a more complete spectroscopic data set for use in product and intermediate analysis. This, in turn, provides students with experiences critical to their ability to operate in a modern research environment.