NMR in the Chemistry Curriculum: An Improvement of Our NMR Capabilities and Practical Applications in Teaching and Research

化学课程中的核磁共振：核磁共振能力的提高及其在教学和研究中的实际应用

• 批准号: 9972479
• 负责人: Rebecca Hoye
• 金额: $ 2万
• 依托单位: Macalester College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9972479&HistoricalAwards=false
• 关键词: NMR; Chemistry; Curriculum; Improvement; Our

The Chemistry Department at Macalester College is upgrading a high field NMR spectrometer for the purpose of interfacing the instrument to the campus network. The goal of this upgrade is to permit students to remotely process data from their undergraduate laboratory experiments. The instrument is a Gemini 300B 300MHz NMR spectrometer (NSF-ILI grant) and is used in student-faculty research effort and in several of undergraduate courses. In order to promote curricular change, gains from NSF supported projects (NSF-CHE 8620242 and NSF-USE 9153106) have been adapted in our sophomore level organic labs and upper level chemistry labs. Organic chemistry students now have greater access to data acquisition and analysis. Upper level adaptations include the use of Fuson's curriculum (NSF-USE-9152169) for studying FT NMR in our Instrumental Analysis course, which places primary emphasis on activities and investigations on the nature of the NMR experiment. Our Advanced Organic Chemistry course provides a suitable backdrop for the introduction of a variety of workhorse 2D NMR techniques to our curriculum. NMR analysis, on combination with our recently acquired molecular modeling capability, spawns open-ended student laboratory projects for the determination of structure and conformation of interesting molecules. Additionally, the works appearing in J. Chem. Ed papers of Mills(1996), Midland (1994), and Lee (1996) are adapted with the goal of developing new pedagogically interesting examples. In this venue students learn to characterize specific arrangements of atoms within molecules with two-dimensional experiments and to study exchange phenomena and the dynamics of molecular interactions.

Macalester学院的化学系正在升级一台高场NMR光谱仪，以便将仪器连接到校园网络。此次升级的目标是允许学生远程处理本科实验室实验的数据。该仪器是Gemini 300 B 300 MHz NMR光谱仪（NSF-ILI资助），用于学生和教师的研究工作和几门本科课程。为了促进课程的变化，从NSF支持的项目（NSF-CHE 8620242和NSF-USE 9153106）的收益已在我们的大二水平的有机实验室和上层化学实验室进行了调整。有机化学专业的学生现在有更多的机会获得数据和分析。上一级的适应包括使用Fuson的课程（NSF-USE-9152169）在我们的仪器分析课程中学习FT NMR，该课程主要强调NMR实验性质的活动和调查。 我们的高级有机化学课程提供了一个合适的背景介绍了各种主力二维核磁共振技术，我们的课程。 NMR分析，结合我们最近获得的分子建模能力，产生了开放式的学生实验室项目，用于确定感兴趣的分子的结构和构象。此外，作品出现在J.化学.艾德论文的米尔斯（1996），米德兰（1994），李（1996）改编的目标是开发新的教学有趣的例子。 在这个场地，学生学习用二维实验来表征分子内原子的特定排列，并研究交换现象和分子相互作用的动力学。