NMR in the Chemistry Curriculum: An Improvement of Our NMR Capabilities and Practical Applications in Teaching and Research

麦卡莱斯特学院化学系正在升级一台高场核磁共振光谱仪，目的是将仪器连接到校园网。这次升级的目标是允许学生远程处理他们本科实验室实验的数据。该仪器是双子座300B 300MHz核磁共振光谱仪（NSF-ILI资助），用于学生和教师的研究工作和几个本科课程。为了促进课程的变化，我们将从国家科学基金会支持的项目（NSF- che 8620242和NSF- use 9153106）中获得的成果应用于二年级有机实验室和高年级化学实验室。有机化学专业的学生现在有更多的机会进行数据采集和分析。上层适应包括使用Fuson的课程（NSF-USE-9152169）在我们的仪器分析课程中研究FT核磁共振，该课程主要强调核磁共振实验性质的活动和调查。我们的高级有机化学课程提供了一个合适的背景，为我们的课程介绍了各种主要的二维核磁共振技术。核磁共振分析与我们最近获得的分子建模能力相结合，产生了开放式的学生实验室项目，以确定有趣分子的结构和构象。此外，在J. Chem。米尔斯（1996）、米德兰（1994）和李（1996）的教育论文被改编为发展新的教学上有趣的例子。在这里，学生将学习用二维实验表征分子内原子的特定排列，并研究分子相互作用的交换现象和动力学。

The Chemistry Department at Macalester College is upgrading a high field NMR spectrometer for the purpose of interfacing the instrument to the campus network. The goal of this upgrade is to permit students to remotely process data from their undergraduate laboratory experiments. The instrument is a Gemini 300B 300MHz NMR spectrometer (NSF-ILI grant) and is used in student-faculty research effort and in several of undergraduate courses. In order to promote curricular change, gains from NSF supported projects (NSF-CHE 8620242 and NSF-USE 9153106) have been adapted in our sophomore level organic labs and upper level chemistry labs. Organic chemistry students now have greater access to data acquisition and analysis. Upper level adaptations include the use of Fuson's curriculum (NSF-USE-9152169) for studying FT NMR in our Instrumental Analysis course, which places primary emphasis on activities and investigations on the nature of the NMR experiment. Our Advanced Organic Chemistry course provides a suitable backdrop for the introduction of a variety of workhorse 2D NMR techniques to our curriculum. NMR analysis, on combination with our recently acquired molecular modeling capability, spawns open-ended student laboratory projects for the determination of structure and conformation of interesting molecules. Additionally, the works appearing in J. Chem. Ed papers of Mills(1996), Midland (1994), and Lee (1996) are adapted with the goal of developing new pedagogically interesting examples. In this venue students learn to characterize specific arrangements of atoms within molecules with two-dimensional experiments and to study exchange phenomena and the dynamics of molecular interactions.