NMR in the Chemistry Curriculum: An Improvement of Our NMR Capabilities and Practical Applications in Teaching and Research

麦卡莱斯特学院化学系正在升级一台高场核磁共振光谱仪，以便将该仪器连接到校园网。这次升级的目标是允许学生远程处理他们本科实验室实验的数据。该仪器是一台Gemini 300B 300 MHz核磁共振波谱仪(NSF-ILI补助金)，用于师生研究工作和几门本科课程。为了促进课程改革，从国家科学基金会资助的项目(国家科学基金会-CHE 8620242和国家科学基金会-使用9153106)中获得的成果已被应用于我们的二年级有机实验室和高级化学实验室。有机化学学生现在有更多的机会获得和分析数据。较高级别的调整包括在我们的仪器分析课程中使用富森的课程(NSF-Use-9152169)来学习FT核磁共振，该课程主要强调活动和对核磁共振实验性质的调查。我们的高级有机化学课程为将各种主要的2D核磁共振技术引入我们的课程提供了合适的背景。核磁共振分析与我们最近获得的分子建模能力相结合，产生了用于确定感兴趣分子的结构和构象的开放式学生实验室项目。此外，出现在J.Chem.米尔斯(1996)、米德兰(1994)和李(1996)的ED论文被改编，目的是开发新的教学有趣的例子。在这个场地里，学生们学习用二维实验描述分子中原子的特定排列，并研究交换现象和分子相互作用的动力学。

The Chemistry Department at Macalester College is upgrading a high field NMR spectrometer for the purpose of interfacing the instrument to the campus network. The goal of this upgrade is to permit students to remotely process data from their undergraduate laboratory experiments. The instrument is a Gemini 300B 300MHz NMR spectrometer (NSF-ILI grant) and is used in student-faculty research effort and in several of undergraduate courses. In order to promote curricular change, gains from NSF supported projects (NSF-CHE 8620242 and NSF-USE 9153106) have been adapted in our sophomore level organic labs and upper level chemistry labs. Organic chemistry students now have greater access to data acquisition and analysis. Upper level adaptations include the use of Fuson's curriculum (NSF-USE-9152169) for studying FT NMR in our Instrumental Analysis course, which places primary emphasis on activities and investigations on the nature of the NMR experiment. Our Advanced Organic Chemistry course provides a suitable backdrop for the introduction of a variety of workhorse 2D NMR techniques to our curriculum. NMR analysis, on combination with our recently acquired molecular modeling capability, spawns open-ended student laboratory projects for the determination of structure and conformation of interesting molecules. Additionally, the works appearing in J. Chem. Ed papers of Mills(1996), Midland (1994), and Lee (1996) are adapted with the goal of developing new pedagogically interesting examples. In this venue students learn to characterize specific arrangements of atoms within molecules with two-dimensional experiments and to study exchange phenomena and the dynamics of molecular interactions.