Using Discovery-Based Experiments to Integrate FT-NMR Spectroscopy into the Chemistry Curriculum

利用基于发现的实验将 FT-NMR 波谱学融入化学课程

• 批准号: 0633149
• 负责人: Julia Baker
• 金额: $ 15万
• 依托单位: Columbia College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0633149&HistoricalAwards=false
• 关键词: Using; Discovery; Based; Experiments; Integrate

Chemistry (12)To improve and modernize its instruction in chemistry, the Department of Biological andPhysical Sciences is adapting a series of discovery-based laboratory experiments to gradually and systematically integrate Fourier transform nuclear magnetic resonance (FT-NMR) spectroscopy into the chemistry curriculum. These experiments, which are being incorporated into seven existing courses (General Chemistry I and II, Organic Chemistry I and II, Physical Chemistry I and II and Biochemistry I) as well as a new spectroscopy course, focus on the use of NMR spectroscopy to answer questions, solve problems, or discover new concepts. These types of inquiry-based activities have been shown to improve student learning and increase student interest in and enthusiasm for the study of science.Intellectual MeritStudents are being introduced to 13C NMR spectroscopy by using a new 90 MHz Anasazi NMR spectrometer in general chemistry in an experiment that examines the concept of isomers and another where they investigate the structure of aspirin. Students are learning 1H and 13C NMR in organic chemistry and are using both 1H and 13C NMR in experiments to identify reaction products and study reaction mechanisms. They also are introduced to two dimensional NMR through a HETCOR experiment. Students in the new spectroscopy course use various NMR experiments and techniques including two dimensional NMR to determine the structures of organic and inorganic unknowns. They also visit the NMR and mass spectrometry laboratories at the University of South Carolina to as part of this course. Students in the biochemistry course use 19F NMR to study enzyme kinetics, and in physical chemistry students use NMR spectroscopy to study reaction kinetics, determine equilibrium constants and to probe spin relaxation effects. With the aid of a local high school teacher, the experiments for general chemistry are being adapted for a high school audience, and high school chemistry classes are invited to Columbia College to carry out these experiments.An Advisory Panel that consists of three faculty members from other predominatelyundergraduate institutions in South Carolina and the Columbia College's Director of Assessment are helping to evaluate this project. Student learning outcomes have been established for each class in which new discovery-based experiments are being introduced.Broader ImpactThrough this project more than 70 women science majors (44% minority) a year are beingexposed to a series of discovery-based labs and are having hand-on experience with theinstrumentation used most routinely for structure determination in modern chemistry laboratories. These students also are developing skills that are enabling them to carry out undergraduate research projects. Through this endeavor, students and faculty at Columbia College are collaborating with faculty at a large research institution and at several other predominately undergraduate institutions within the state. The Columbia College faculty also are broadening their interactions with local high school teachers and students. Results of this project will be disseminated into the chemical education community through conferences and meetings, peer-reviewed journals and through the formation of a South Carolina Anasazi Instrument User's Group.

化学（12）为了改善和现代化的化学教学，生物和物理科学系正在适应一系列基于发现的实验室实验，逐步和系统地将傅里叶变换核磁共振（FT-NMR）光谱学整合到化学课程中。这些实验，这是被纳入七个现有的课程（普通化学I和II，有机化学I和II，物理化学I和II和生物化学I）以及一个新的光谱学课程，专注于使用NMR光谱回答问题，解决问题，或发现新的概念。这些以探究为基础的活动已被证明可以提高学生的学习效果，并提高学生对科学研究的兴趣和热情。智力优势在普通化学实验中，学生将使用新的90 MHz Anasazi NMR光谱仪进行13 C NMR光谱学实验，以检查异构体的概念，并在另一个实验中研究阿司匹林的结构。学生正在学习有机化学中的1H和13 C NMR，并在实验中使用1H和13 C NMR来识别反应产物和研究反应机理。并通过HETCOR实验将它们引入到二维NMR中。新光谱学课程的学生使用各种NMR实验和技术，包括二维NMR，以确定有机和无机未知物的结构。他们还参观了南卡罗来纳州大学的核磁共振和质谱实验室，作为本课程的一部分。 生物化学课程的学生使用19 F NMR研究酶动力学，物理化学课程的学生使用NMR光谱学研究反应动力学，确定平衡常数和探测自旋弛豫效应。在当地一位高中教师的帮助下，普通化学实验正在适应高中的观众，高中化学班被邀请到哥伦比亚学院进行这些实验，一个由来自南卡罗来纳州其他主要本科院校的三名教师组成的咨询小组和哥伦比亚学院的评估主任正在帮助评估这个项目。学生的学习成果已经建立了每一个班级，其中新的发现为基础的实验正在引入。更广泛的影响通过这个项目，超过70名女性科学专业（44%少数民族）每年被暴露在一系列的发现为基础的实验室，并有动手的经验与仪器最常用的结构测定在现代化学实验室。这些学生也正在发展技能，使他们能够开展本科研究项目。 通过这一奋进，哥伦比亚学院的学生和教师正在与一个大型研究机构和该州其他几个主要本科院校的教师合作。哥伦比亚学院的教师也在扩大与当地高中教师和学生的互动。该项目的成果将通过各种会议、同行评审期刊和成立南卡罗来纳州阿纳萨齐仪器用户小组的方式向化学教育界传播。