Using Discovery-Based Experiments to Integrate FT-NMR Spectroscopy into the Chemistry Curriculum

化学(12)为了改进其化学教学并使其现代化，生物与物理科学系正在调整一系列以发现为基础的实验室实验，以逐步和系统地将傅立叶变换核磁共振(FT-核磁共振)光谱学纳入化学课程。这些实验正在纳入现有的七门课程(普通化学I和II，有机化学I和II，物理化学I和II以及生物化学I)以及一门新的光谱学课程，重点是使用核磁共振光谱学来回答问题、解决问题或发现新概念。这些类型的探究式活动已被证明改善了学生的学习，提高了学生对科学研究的兴趣和热情。智力价值通过在普通化学中使用新的90 MHz Anasazi核磁共振谱仪，向学生介绍13C核磁共振波谱，在一个实验中，他们检验了异构体的概念，另一个实验中，他们研究了阿司匹林的结构。学生正在学习有机化学中的~1H和~(13)C核磁共振，并在实验中同时使用~1H和~(13)C核磁共振来鉴定反应产物和研究反应机理。并通过HETCOR实验将它们引入到二维核磁共振中。新的光谱学课程的学生使用各种核磁共振实验和技术，包括二维核磁共振来确定有机和无机未知物的结构。作为课程的一部分，他们还参观了南卡罗来纳大学的核磁共振和质谱学实验室。生物化学课程的学生使用19F核磁共振研究酶的动力学，物理化学的学生使用核磁共振波谱研究反应动力学，测定平衡常数和探索自旋松弛效应。在当地一名高中老师的帮助下，普通化学实验正在被改编成适合高中观众的实验，高中化学班级被邀请到哥伦比亚学院进行这些实验。一个由来自南卡罗来纳州其他主要本科院校的三名教职员工和哥伦比亚大学评估主任组成的顾问小组正在帮助评估这个项目。通过这个项目，每年有70多名女理科专业(44%的少数人)接触到一系列基于发现的实验室，并对现代化学实验室中最常用的结构确定仪器有实践经验。这些学生还在发展技能，使他们能够进行本科生研究项目。通过这一努力，哥伦比亚学院的学生和教职员工正在与该州一家大型研究机构和其他几家以本科生为主的机构的教职员工合作。哥伦比亚学院的教职员工也在扩大与当地高中教师和学生的互动。该项目的成果将通过各种会议、同行评议的期刊以及成立南卡罗来纳州阿纳萨齐仪器用户小组向化学教育界传播。

Chemistry (12)To improve and modernize its instruction in chemistry, the Department of Biological andPhysical Sciences is adapting a series of discovery-based laboratory experiments to gradually and systematically integrate Fourier transform nuclear magnetic resonance (FT-NMR) spectroscopy into the chemistry curriculum. These experiments, which are being incorporated into seven existing courses (General Chemistry I and II, Organic Chemistry I and II, Physical Chemistry I and II and Biochemistry I) as well as a new spectroscopy course, focus on the use of NMR spectroscopy to answer questions, solve problems, or discover new concepts. These types of inquiry-based activities have been shown to improve student learning and increase student interest in and enthusiasm for the study of science.Intellectual MeritStudents are being introduced to 13C NMR spectroscopy by using a new 90 MHz Anasazi NMR spectrometer in general chemistry in an experiment that examines the concept of isomers and another where they investigate the structure of aspirin. Students are learning 1H and 13C NMR in organic chemistry and are using both 1H and 13C NMR in experiments to identify reaction products and study reaction mechanisms. They also are introduced to two dimensional NMR through a HETCOR experiment. Students in the new spectroscopy course use various NMR experiments and techniques including two dimensional NMR to determine the structures of organic and inorganic unknowns. They also visit the NMR and mass spectrometry laboratories at the University of South Carolina to as part of this course. Students in the biochemistry course use 19F NMR to study enzyme kinetics, and in physical chemistry students use NMR spectroscopy to study reaction kinetics, determine equilibrium constants and to probe spin relaxation effects. With the aid of a local high school teacher, the experiments for general chemistry are being adapted for a high school audience, and high school chemistry classes are invited to Columbia College to carry out these experiments.An Advisory Panel that consists of three faculty members from other predominatelyundergraduate institutions in South Carolina and the Columbia College's Director of Assessment are helping to evaluate this project. Student learning outcomes have been established for each class in which new discovery-based experiments are being introduced.Broader ImpactThrough this project more than 70 women science majors (44% minority) a year are beingexposed to a series of discovery-based labs and are having hand-on experience with theinstrumentation used most routinely for structure determination in modern chemistry laboratories. These students also are developing skills that are enabling them to carry out undergraduate research projects. Through this endeavor, students and faculty at Columbia College are collaborating with faculty at a large research institution and at several other predominately undergraduate institutions within the state. The Columbia College faculty also are broadening their interactions with local high school teachers and students. Results of this project will be disseminated into the chemical education community through conferences and meetings, peer-reviewed journals and through the formation of a South Carolina Anasazi Instrument User's Group.