Using Discovery-Based Experiments to Integrate FT-NMR Spectroscopy into the Chemistry Curriculum

为了改进和现代化化学教学，生物与物理科学系正在调整一系列基于发现的实验室实验，逐步系统地将傅里叶变换核磁共振（FT-NMR）光谱学纳入化学课程。这些实验被纳入现有的七门课程（普通化学I和II、有机化学I和II、物理化学I和II和生物化学I）以及一门新的光谱学课程，重点是利用核磁共振光谱学来回答问题、解决问题或发现新概念。这些以探究为基础的活动已经被证明可以改善学生的学习，增加学生对科学研究的兴趣和热情。在普通化学实验中，学生们通过使用新的90 MHz Anasazi核磁共振波谱仪来了解13C核磁共振波谱，以检验异构体的概念，并在另一个实验中研究阿司匹林的结构。学生正在学习有机化学中的1H和13C核磁共振，并在实验中使用1H和13C核磁共振来识别反应产物和研究反应机理。通过HETCOR实验，介绍了二维核磁共振。在新的光谱学课程中，学生使用各种核磁共振实验和技术，包括二维核磁共振来确定有机和无机未知物质的结构。他们还参观了南卡罗来纳大学的核磁共振和质谱实验室，作为本课程的一部分。生物化学课程的学生使用19F核磁共振来研究酶动力学，物理化学课程的学生使用核磁共振波谱来研究反应动力学，确定平衡常数并探测自旋弛豫效应。在当地一位高中老师的帮助下，普通化学实验正被改编成适合高中观众的实验，高中化学班被邀请到哥伦比亚大学进行这些实验。咨询小组由来自南卡罗来纳其他主要本科院校的三名教员和哥伦比亚学院的评估主任组成，他们正在帮助评估这个项目。学生的学习成果已经为每个班级建立，其中引入了新的基于发现的实验。更广泛的影响通过这个项目，每年有70多名理科专业的女学生（44%为少数族裔）接触到一系列以发现为基础的实验室，并获得了在现代化学实验室中最常用的结构测定仪器的实践经验。这些学生也在发展技能，使他们能够开展本科研究项目。通过这一努力，哥伦比亚学院的学生和教职员工正在与一家大型研究机构以及该州其他几家以本科生为主的机构的教职员工合作。哥伦比亚学院的教师也在扩大与当地高中教师和学生的互动。该项目的成果将通过各种会议、同行评议的期刊和成立南卡罗来纳州阿纳萨齐仪器用户小组的方式向化学教育界传播。

Chemistry (12)To improve and modernize its instruction in chemistry, the Department of Biological andPhysical Sciences is adapting a series of discovery-based laboratory experiments to gradually and systematically integrate Fourier transform nuclear magnetic resonance (FT-NMR) spectroscopy into the chemistry curriculum. These experiments, which are being incorporated into seven existing courses (General Chemistry I and II, Organic Chemistry I and II, Physical Chemistry I and II and Biochemistry I) as well as a new spectroscopy course, focus on the use of NMR spectroscopy to answer questions, solve problems, or discover new concepts. These types of inquiry-based activities have been shown to improve student learning and increase student interest in and enthusiasm for the study of science.Intellectual MeritStudents are being introduced to 13C NMR spectroscopy by using a new 90 MHz Anasazi NMR spectrometer in general chemistry in an experiment that examines the concept of isomers and another where they investigate the structure of aspirin. Students are learning 1H and 13C NMR in organic chemistry and are using both 1H and 13C NMR in experiments to identify reaction products and study reaction mechanisms. They also are introduced to two dimensional NMR through a HETCOR experiment. Students in the new spectroscopy course use various NMR experiments and techniques including two dimensional NMR to determine the structures of organic and inorganic unknowns. They also visit the NMR and mass spectrometry laboratories at the University of South Carolina to as part of this course. Students in the biochemistry course use 19F NMR to study enzyme kinetics, and in physical chemistry students use NMR spectroscopy to study reaction kinetics, determine equilibrium constants and to probe spin relaxation effects. With the aid of a local high school teacher, the experiments for general chemistry are being adapted for a high school audience, and high school chemistry classes are invited to Columbia College to carry out these experiments.An Advisory Panel that consists of three faculty members from other predominatelyundergraduate institutions in South Carolina and the Columbia College's Director of Assessment are helping to evaluate this project. Student learning outcomes have been established for each class in which new discovery-based experiments are being introduced.Broader ImpactThrough this project more than 70 women science majors (44% minority) a year are beingexposed to a series of discovery-based labs and are having hand-on experience with theinstrumentation used most routinely for structure determination in modern chemistry laboratories. These students also are developing skills that are enabling them to carry out undergraduate research projects. Through this endeavor, students and faculty at Columbia College are collaborating with faculty at a large research institution and at several other predominately undergraduate institutions within the state. The Columbia College faculty also are broadening their interactions with local high school teachers and students. Results of this project will be disseminated into the chemical education community through conferences and meetings, peer-reviewed journals and through the formation of a South Carolina Anasazi Instrument User's Group.