SGER: Advanced X-ray Study for Biomedical Imaging

9974345Mitra调查的目的是解释使用具有高能量放大发射的超快激光脉冲来产生与医学相关的硬剂量X射线的可行性。如果被证明是可行的，预计可以开发一种时间门控X射线技术来对模体进行成像，从早期检测、剂量水平和分辨率的角度来看，这将大大超过传统X射线系统的能力。这种方法的成功演示有许多优势，可以利用当今的激光技术实现：分辨率将提高一个数量级(在今天的X射线管中，激光可以聚焦到十微米直径，而不是十分之一毫米)；一个数量级的较小来源意味着可以发现十分之一大小的更小的肿瘤或病变；散射噪声将通过时间门控探测器减少，从而产生更高的图像信噪比(SNR)5倍或更多。调查和高风险调查旨在获得确认该技术可行性所需的基本知识。最终的回报将是提高我们在早期阶段以较低剂量发现乳腺癌的能力。这项研究是作为探索性研究的小额赠款(SGER)资助的。

9974345MitraThe purpose of the investigation is to explain the feasibility of using ultra-fast laser pulses with high energy amplified emission to generate hard, medically relevant doses of x-rays. If shown to be feasible, it is anticipated that a time-gated x-ray technology could be developed for the imaging of phantoms that would greatly exceed the capability of conventional x-ray systems from the point of view of early detection, dosage level, and resolution. Successful demonstration of this approach has many advantages and can be accomplished with today's laser technology: resolution would be increased by an order of magnitude (lasers can be focused to ten microns diameter rather than tenths of a millimeter in today's X-ray tubes); an order of magnitude smaller source means that a one-tenth size smaller tumor or lesion could be found; scattering noise would be reduced by the time-gated detector thereby yielding a higher signal-to-noise ration (SNR) of the image by a factor of 5 or more.The investigation and high risk investigation is designed to obtain fundamental knowledge needed to confirm the feasibility of the technology. The eventual pay-off would be high in enhancing our ability to detect breast cancer at an earlier stage and with a lower dose. This investigation is funded as a Small Grant for Exploratory Research (SGER).