SGER: Advanced X-ray Study for Biomedical Imaging

9974345Mitra 研究的目的是解释使用具有高能放大发射的超快激光脉冲产生硬的、医学相关剂量的 X 射线的可行性。 如果被证明是可行的，预计可以开发出时间选通 X 射线技术来对模型进行成像，从早期检测、剂量水平和分辨率的角度来看，该技术将大大超过传统 X 射线系统的能力。 这种方法的成功演示具有许多优点，并且可以通过当今的激光技术来实现：分辨率将提高一个数量级（激光可以聚焦到十微米直径，而不是当今 X 射线管中的十分之一毫米）；源小一个数量级意味着可以发现体积小十分之一的肿瘤或病变；时间选通探测器将减少散射噪声，从而使图像的信噪比 (SNR) 提高 5 倍或更多。调查和高风险调查旨在获得确认该技术可行性所需的基础知识。 最终的回报将是提高我们在早期阶段以较低剂量检测乳腺癌的能力。 这项调查由探索性研究小额赠款 (SGER) 资助。

9974345MitraThe purpose of the investigation is to explain the feasibility of using ultra-fast laser pulses with high energy amplified emission to generate hard, medically relevant doses of x-rays. If shown to be feasible, it is anticipated that a time-gated x-ray technology could be developed for the imaging of phantoms that would greatly exceed the capability of conventional x-ray systems from the point of view of early detection, dosage level, and resolution. Successful demonstration of this approach has many advantages and can be accomplished with today's laser technology: resolution would be increased by an order of magnitude (lasers can be focused to ten microns diameter rather than tenths of a millimeter in today's X-ray tubes); an order of magnitude smaller source means that a one-tenth size smaller tumor or lesion could be found; scattering noise would be reduced by the time-gated detector thereby yielding a higher signal-to-noise ration (SNR) of the image by a factor of 5 or more.The investigation and high risk investigation is designed to obtain fundamental knowledge needed to confirm the feasibility of the technology. The eventual pay-off would be high in enhancing our ability to detect breast cancer at an earlier stage and with a lower dose. This investigation is funded as a Small Grant for Exploratory Research (SGER).