EAGER: Non-invasive Cerbrovascular Regulation Assessment

PI: Mitra， Kunal提案号：1435511机构：Florida Institute of technology标题：EAGER：无创脑血管调节评估目前迫切需要一种便携式、客观的无创工具来评估持续性脑震荡（CHI）患者的生理性脑功能障碍。已知CHI会引起脑血流紊乱以及神经心理（NP）症状。目前的临床评估完全依赖于NP测试，缺乏客观的诊断标准，也不能表明实际脑损伤的存在。许多NP测试结果正常的患者可以恢复以前的活动，但实际上他们身体受损，并且更容易遭受重复伤害。提出的传感器和新算法可能为CHI患者的初始检测、评估、监测和康复提供至关重要的工具。脑震荡通常会导致身体脑损伤和脑血流控制功能障碍，而目前的神经心理学测试方法往往无法检测到这一点。用现有的工具对功能障碍进行客观测量是困难的。这个问题将通过实施脑血氧仪和血流描记术（脑生物阻抗）以及新的算法来研究，以评估控制CBF的机制。本研究的主要目的是确定这两种易于实现的无创设备是否可以在不需要额外传感器的情况下组合使用，以评估脑血管功能，并探索可用于临床评估的实验方案。健康志愿者将被用于研究，以建立基线规范和优化测试方案。研究方法包括以预定的间隔吸入环境空气和空气与二氧化碳的混合物。传感器对二氧化碳吸入预期血管舒张反应的反应将被分析二氧化碳浓度、吸入持续时间和重复吸入挑战（即趋势）的影响。研究结果将用于制定方案和调整传感器参数，以用于脑震荡后CBF控制受损个体的未来研究。

PI: Mitra, Kunal Proposal Number: 1435511Institution: Florida Institute of TechnologyTitle: EAGER: Non-invasive Cerbrovascular Regulation AssessmentA critical need exists for a portable and objective noninvasive tool to evaluate physiological cerebral dysfunction in patients who have sustained concussive head injury (CHI). CHI is known to cause disturbances in brain blood flow as well as neuropsychological (NP) symptoms. Current clinical assessments rely entirely on NP testing, which lack objective diagnostic criteria and do not indicate the presence of actual brain injury. Many patients with normal NP test findings are cleared to resume previous activities, yet are in fact physically impaired and have heightened vulnerability to repeat injury. The proposed sensors and novel algorithms may provide crucially needed tools for initial detection, assessment, monitoring, and rehabilitation of individuals with CHI. Concussion often causes physical brain injury and dysfunctional control of cerebral blood flow (CBF), which is often undetected by current neuropsychological test methods. Objective measurement of dysfunction is difficult with currently available tools. This problem will be investigated by implementing cerebral oximetry and rheoencephalography (cerebral bioimpedance), together with novel algorithms, to evaluate mechanisms that control CBF. The primary objective of this research is to determine whether these two easily implemented noninvasive devices can be used in combination, without the need for additional sensors, to assess cerebrovascular function, and to explore experimental protocols that could be used in clinical evaluations. Healthy volunteers will be used in the study in order to establish baseline norms and optimize test protocols. The research methods include inhalation of ambient air and a mixture of air and CO2 at predetermined intervals. Sensor responses to the expected vasodilatory response from CO2 inhalation will be analyzed for the effects of CO2 concentration, duration of inhalation, and repeated inhalation challenges (i.e., trending). The results will be used to develop protocols and adjust the sensor parameters for future studies in post-concussive individuals with impaired CBF control.