A Web-based Relational Database for Thermodynamic and Structure Data on Lipids

项目摘要DBI 9981990 Caffrey俄亥俄州州立大学一个基于网络的脂质热力学和结构数据的关系数据库选择性渗透膜是活细胞的基本特征。膜是一种双分子脂质小叶，蛋白质和其他分子位于其中或其上。脂质介晶性，或液晶性，使膜处于双层稳定性的边缘，从而调节膜功能。在过去的三十年里，生物化学和生物物理学界对生物和合成脂质的介晶性质的兴趣极大地增长。因此，存在着丰富的关于脂相行为的信息，其中大部分分散在整个文献中。本提案的目的是提供现成的网络访问这些数据，脂质分子结构和适当的文献在一个不断更新的关系数据库和数据提交和分析的网络手段。数据有两种形式。第一个是指在不同的水化状态下的脂质的相变类型，温度和相变率。第二个是关于脂的溶解性，用图表表示为常压和等温相图。该项目是跨学科的，因为它结合了一位从事脂质和膜结构生物学的生物化学家和一位具有数据库专业知识的计算机科学家的努力。http://www.lipidat.chemistry.ohio-state.edu

Project AbstractDBI 9981990 Caffrey Ohio State University A web-based Relational Database for Thermodynamic and Structure Data on LipidsSelectively permeable membranes are an essential feature of living cells. The membrane is a bimolecular lipid leaflet in and on which are situated proteins and other molecules. Lipid mesomorphism, or liquid crystallinity, allows for the positioning of the membrane on the verge of bilayer stability thereby modulatingmembrane function. Interest in the mesomorphic properties of biological and synthetic lipids within the biochemistry and biophysics communities has grown enormously in the past three decades. As a result, there exists a wealth of information on lipid phase behavior, much of which is scattered throughout theliterature. The objective of this proposal is to provide ready web access to these data, to lipid molecular structures and to the appropriate literature in a continuously updated relational database and a means for data submission and analysis over the web. The data come in two forms. The first refers to phase transition types, temperatures and enthalpies for lipids in different hydration states. The second concerns lipid miscibility represented graphically asisobaric and isothermal phase diagrams. The project is cross-disciplinary in that it combines the efforts of a biochemist working on lipids and membrane structural biology and a computer scientist with database expertise.URL: http://www.lipidat.chemistry.ohio-state.edu